Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that impair neuronal function. The resultant synaptopathy causes behavioural deficits and progressive age-related neurodegeneration. This
succession of phenotypes recapitulates key events of dying-back like neurodegeneration5,27,92 and provide insights into the pathogenic mechanisms underlying synaptopathy, the likely initiating event in Parkinson’s disease and related synucleinopathies. CLICK TO REVIEW