Ethanol (EtOH) is associated with IBD flares, but the exact mechanisms are not well-known. Gut dysbiosis and depleted luminal butyrate are both linked with IBD and EtOH exposure. We tested our hypothesis that EtOH-induced gut dysbiosis and depleted butyrate levels disrupt intestinal epithelial junctional proteins which facilitates ethanol and endotoxin interaction with intestinal microvascular endothelial cells and activates them. CLICK TO REVIEW