BDNF

Effects of Intermittent Fasting On Cognition and
Neurodegeneration

Fasting, Parkinson's Disease /

Intermittent fasting (IF) can facilitate neurodegenerative, neuroadaptive and neuroprotective processes leading toprofound effects on cognition and dementias. The impact that IF has on the central nervous system is still not fullyknown. Several factors come into likely effect including changes in energy metabolism, oxidative damage, insulinsensitivity, inflammation, and functional changes related to various neurotransmitters and hormones. […]

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Neurodegeneration Read More »

Exercise training increase brain-derived neurotrophic factor and irisin level in healthy young adults in
Basra city

Diet and Exercise /

Regular treadmill exercise is more efficient than voluntary in neuroprotection by changing brain metabolism, at the moment, regulartreadmill exercise has been observed to improve many physiological impacts in humans and animals. The present study sought to verifythe effect of regular treadmill exercise on brain-derived neurotrophic factor (BDNF) and irisin in healthy adult’s men in Basra

Exercise training increase brain-derived neurotrophic factor and irisin level in healthy young adults in
Basra city Read More »

Is Fasting Good For Your Brain? The Effects of Fasting on the Brain

Autophagy, Fasting, Parkinson's Disease, Pre-PD /

Fasting promotes autophagy, a vital recycling process, and stimulates the growth factor BDNF. Autophagy is impaired in neurodegenerative conditions such as Alzheimer’s and Parkinson’s. BDNF is crucial for brain health, and low levels are associated with depression. Hence, fasting improves brain health by multiple mechanisms. While fasting has been performed in one form or another

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Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery

Autophagy, Parkinson's Disease /

Brain-derived neurotrophic factor (BDNF) is a protein that performs a neurotrophic function.BDNF and its receptors are widely expressed in the nervous system and can promote the growthof neurons and the formation of neuronal synapses in the brain. Studies have shown that a lack ofBDNF can lead to impairment of memory and cognitive functions, indicating that

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Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor

A-Synuclein /

Within this review, we will present a comprehensive overview of the data linking synuclein-associated Lewy pathology with intracellular dysfunction. We first present the alterations in neuronal proteins and transcriptome associated with LBs in postmortem human PD tissue. We next compare these findings to those associated with LB-like inclusions initiated by in vitro exposure to α-syn

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Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics

Parkinson's Disease, Therapies /

In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or its interaction with aging, will aid in the development of safe and optimized therapeutic approaches for remodeling the parkinsonian striatum. CLICK TO REVIEW

Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics Read More »

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Diet and Exercise /

As a member of the neurotrophin family, BDNF regulates many of the processes within neurogenesis, such as differentiation and survival. Although much more is known about the direct role that exercise and BDNF have on hippocampal neurogenesis in rodents, their corresponding cognitive benefits in humans will also be discussed. Specifically, what is known about exercise-mediated

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Brain-derived neurotrophic factor (BDNF)

Diet and Exercise, Gut-Brain axis, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Brain-derived neurotrophic factor, or BDNF, is a growth factor with broad relevance for aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays key roles in numerous signaling pathways associated with a variety of disorders ranging from depression, schizophrenia, and addiction to obesity and diabetes, and may serve

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