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Impact of Probiotic and Prebiotic on Gut Microbiota in Pre-diabetes and Type 2 Diabetes

Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The increased worldwide prevalence of pre-diabetes and diabetes, especially type 2 diabetes, requiring different strategies for their prevention and management. A new focus is the reversal of diabetes dysbiosis, a disruption of gut microbiota homeostasis, which is closely related to elevated blood glucose levels and altered metabolic parameters. In this sense, a balanced diet plays a key role, and, […]

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Effects of Endurance Training on Motor Signs of Parkinson’s Disease: A Systematic Review and Meta-Analysis

Parkinson's Disease /

Evidence has demonstrated that endurance training (ET) reduces the motor signs of Parkinson’s disease (PD). However, there has not been a comprehensive meta-analysis of studies to date. ET is effective in decreasing UPDRS-III scores. Questions remain about the dose–response relationship between ET and reduction in motor signs. CLICK TO REVIEW

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Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases?

endondonics, Endotoxin, Periodontitis /

Apical periodontitis (AP) or periapical lesion (PL) is an inflammatory disease that causes pain, loss of bone and destruction of other tissues of teeth support. This condition could be caused by caries, dental trauma and/or periapical microleakage wich is regulated by the immune system or inflammatory response. Several analyses have shown that endodontic infection can

Periapical Disease and the Prefrontal Cortex. Is there a Relationship between Calcium-Binding Protein and Neurodegenerative Diseases? Read More »

Gut microbiota related to nutrition and physical activity: an integrative review

Diet and Exercise, Gut Microbiota /

The gut microbiota (GM) is formed by millions of microorganisms present in the gastrointestinal tract, especially in the colon. This intestinal homeostasis can be triggered by the union of a good diet, and even recent studies have suggested that aerobic physical training can modify its composition. Objective:To analyze the influence of healthy eating added to

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

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Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review

Periodontitis, Root Canal /

All the included studies reported higher levels of inflammatory markers, IgG levels of periodontal bacteria, and/or clinical parameters of periodontitis with the two concomitant diseases (some neurodegenerative disease and periodontitis), compared with the diseases isolated (summarized in Figure 2). Despite that we found some minor problems in domains in the qualitative analysis, all the studies have

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Gut-brain axis and immunoneuroendocrine modulation in neurological and psychiatric disorders: Asystematic review

Short Chain Fatty Acids /

Communication between the GI tract and the CNS occurs via the neuronal,endocrine, and immunological pathways through a) the production of neurotransmitters, b) the tryptophan metabolism, c) the modulation of the immunological activity in the CNS and the SNE, d) production of short chain fatty acids, e) the production of intestinal hormones, and f) the production

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microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson’s disease as noninvasive biomarkers

iRBD, Pre-PD /

The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood and sleep changes are often manifested. REM-sleep behavior disorder (RBD) is the prodromal manifestation with the highest odds for conversion into PD, thereby a valuable phenotype for disease prediction. The present review focuses on microRNAs’

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Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson’s disease

Biomarkers, Dementia - Lewy Bodies, iRBD, Symptoms / Diagnosis /

This article aimed at critically reviewing the literature on the controversies about the prevalence of RBD in PD, the higher incidence of PD non-motor symptoms associated with RBD, the evidence of faster motor worsening in parkinsonian patients with this parasomnia, and the main pathophysiological hypotheses that support these findings. CLICK TO REVIEW

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