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Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?

Enviromental, Glyphosate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Environmental exposure to glyphosate and glyphosate-based herbicides has the potential to negatively influence neurodevelopment and behavior across generations indirectly through the gut-brain-microbiome axis. Potential mechanisms by which glyphosate may elicit these effects are through the disruption of the normally symbiotic relationship of the host and the gut microbiome. Given glyphosate can kill commensal members of […]

Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis? Read More »

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Anti-oxidants, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases Read More »

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may

Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases Read More »

Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases

Parkinson's Disease /

Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent

Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases Read More »

Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study

iRBD, Pre-PD /

Background:Prodromal multiple system atrophy (MSA) has been characterized mainly by retrospective chart reviews. Direct observation and tracking of prodromal markers in MSA have been very limited Objective:To report the baseline characteristics and evolution of prodromal markers of MSA as they were prospectively measured in patients with idiopathic/isolated REM sleep behavior disorder (iRBD) Methods:Patients with iRBD were

Evolution of Prodromal Multiple System Atrophy from REM Sleep Behavior Disorder: A Descriptive Study Read More »

CORE ONE LABS’ AKOME SEEKS TO REVOLUTIONIZE TREATMENT OF PARKINSON’S DISEASE AND SUBMITS APPLICATION TO PROTECT IP

Ayahuasca, Parkinson's Disease, Pre-PD /

Akome’s AKO004 psychedelic drug formulation, for use in the treatment of Parkinson’s disease, is a composition comprising the psychedelic compound N,N-dimethyltryptamine (DMT) and, a specifically chosen, naturally occurring plant bioactive.  Initial data analysis indicates that the AKO004 composition is safe and efficacious for use, and presents many positive properties which may counter or mitigate neurodegeneration

CORE ONE LABS’ AKOME SEEKS TO REVOLUTIONIZE TREATMENT OF PARKINSON’S DISEASE AND SUBMITS APPLICATION TO PROTECT IP Read More »

The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a complex brain disorder involving a multitude ofcontributing factors ranging from environmental to genetic. Interestingly, it has been foundthat the gut microbial community is altered in PD patients when compared to that of non-PDindividuals. However, the factors contributing to altered gut microbiota remain largelyunexplored. As such, the first objective of our

The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients Read More »

Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial

Diet and Exercise, Parkinson's Disease /

A significant interaction effect between groups and time were observed F(1, 39) = 4.566, P = .036, where the sensory group improved in comparison to the boxing group. Post hoc analysis revealed that in comparison to boxing, the effects of exercise did not wear off at washout (week 20) P < .006. Conclusion. Future rehabilitation

Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial Read More »

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

These data indicate that pathogen disruption of the epithelial mitochondrial network is a component of IBD that could identify novel targets to control enteric inflammation. These data underscore the complex bacterial-epithelium interaction: commensal organisms may preserve the mitochondrial network in the face of challenge from pathogens that seek to disrupt mitochondrial form and function. CLICK

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection Read More »