China

Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease

A-Synuclein, Gut-Brain axis, iRBD /

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is […]

Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease Read More »

Research progress on the association of neurological disorders and periodontal diseases

endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD /

Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases

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Microbiota in health and diseases

Gut Microbiota, Gut-Brain axis /

The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on thelocalized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are insymbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead todysregulation of bodily

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Phenoconversion Risk Factors in Rapid Eye Movement Sleep Behavior Disorder

Biomarkers, Enviromental, iRBD, Parkinson's Disease, Pesticides, Pre-PD /

A multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD) was studied to determine any predictive factors for α-synuclein–related neurodegenerative illnesses. At the start of the study, patients with iRBD from 12 different sites were given a complete assessment for potential environmental and lifestyle risk factors using a standardized questionnaire. Patients were then

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Modulation of gut health using probiotics: the role of probiotic effector molecules

Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Probiotics affect intestinal metabolism and play a crucial role in gut homeostasis. Studies on probiotic effector molecules—bacteriocins, peptidoglycan, teichoic acid, exopolysaccharides, secretory proteins, and short-chain fatty acids—describe their effect on the gut barrier; immune and nervous system; and gut microbiota. However, the detailed mechanism of how the intestinal microbiota changes after the intervention of effector

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Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate

Butyrate, Gut Dysbiosis, Gut Microbiota, Lipopolysaccharides (LPS), Metabolites, Short Chain Fatty Acids /

Our data indicate a cause–effect relationship between gut microbiota and PSCI for the first time, which is likely mediated by inflammation-regulating metabolites including LPS and butyrate. CLICK TO REVIEW

Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate Read More »

Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression

iRBD, Parkinson's Disease, Pre-PD /

The course of REM sleep behavior disorder (RBD) variates in the early stage of Parkinson’s disease. We aimed to delineate the association between the evolution pattern of probable RBD (pRBD) and the progression of Parkinson’s disease (PD). 281 de novo PD patients from the Parkinson’s Progression Markers Initiative database were included. Patients were followed up

Evolution patterns of probable REM sleep behavior disorder predicts Parkinson’s disease progression Read More »

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights

A-Synuclein, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuronal loss andα-synuclein (α-syn) aggregation. With the acceleration of population aging process, the incidence of PD is expected toincrease, putting a heavy burden on the whole society. Recent studies have found the alterations of gut microbiota (GM) inPD patients and the clinical relevance of

Gut microbiota and inflammation in
Parkinson’s disease: Pathogenetic and
therapeutic insights Read More »

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Parkinson’s disease (PD) presents a common challenge for people all over the world and has become a major research hotspot due to the large population affected by the illness and the difficulty of clinical treatment. The prevalence of PD is increasing every year, the pathogenesis is complex, and the current treatment is ineffective. Therefore, it has

The potential applications of traditional Chinese medicine in Parkinson’s disease: A new opportunity Read More »

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

Gut Dysbiosis, Gut-Brain axis, Parkinson's Disease, Pre-PD /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »