China

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management

A-Synuclein, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The identification of Parkinson’s disease (PD) is mainly dependent on motorsymptoms, while the non-motor symptoms exist even decades ahead of the PDdiagnosis. According to Braak’s hypothesis, the enteric plexus is the first affectedsite during the pathological development of PD, and gastrointestinal (GI) symptomsappear during the onset of the disease. Although GI symptoms decrease the lifequality […]

Gastrointestinal symptoms of Parkinson’s
disease: A systematic review from pathogenesis
to management Read More »

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice

Butyrate, Metabolites, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The substantially increased prevalence of obesity and obesity-relateddiseases has generated considerable concern. Currently, synthetic biological strategieshave played an essential role in preventing and treating chronic diseases such as obesity.A growing number of symbiotic bacteria used as vectors for genetic engineering havebeen applied to create living therapeutics. In this study, using Bacillus subtilis as a cellularchassis,

Positive Interventional Effect of Engineered Butyrate-Producing
Bacteria on Metabolic Disorders and Intestinal Flora Disruption
in Obese Mice Read More »

Roles of oral microbiota and oral-gut microbial transmission in hypertension

Gut-Brain axis, Oral Microbiome, Periodontitis /

Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading to PD is known to aggravate different systematic diseases, but the alteration of oral microbiota in HTN and their impacts on blood pressure (BP) remains to be discovered. CLICK TO REVIEW

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Dual role of the nasal microbiota in neurological diseases—An unignorable risk factor or a potential therapy carrier

Gut Dysbiosis, Mitochondria, Olfactory, Parkinson's Disease /

Recently, comparative studies have rapidly increased with the closer correlation between microbiota and neurological diseases. However, most insights about the association between microbiota and neurological diseases still focus on the gut-brain axis and ignore that nasal microbiota could form a complex and essential link with the nervous system via the nose-to-brain pathway, suggesting the role

Dual role of the nasal microbiota in neurological diseases—An unignorable risk factor or a potential therapy carrier Read More »

Effects of Cannabidiol on Parkinson’s Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis

CBD, Parkinson's Disease /

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical PD motor symptoms. The therapeutic effect of cannabidiol (CBD) on PD has been a research frontier in recent years. However, the pathogenesis of PD and the therapeutic mechanism of cannabinoid remain unclear. To further

Effects of Cannabidiol on Parkinson’s Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis Read More »

Oral microbiomes: more and more importance in oral cavity and whole body

Oral Microbiome, Periodontitis /

Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play

Oral microbiomes: more and more importance in oral cavity and whole body Read More »

Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota

Butyrate, Oral Microbiome, Periodontitis /

Postmenopausal osteoporosis (PMO) is a risk factor for periodontitis, and current therapeutics against PMO prevent the aggravated alveolar bone loss of periodontitis in estrogen-deficient women. Gut microbiota is recognized as a promising therapeutic target for PMO. Berberine extracted from Chinese medicinal plants has shown its effectiveness in the treatment of metabolic diseases such as obesity

Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota Read More »

Oral microbiota in human systematic diseases

Oral Microbiome, Periodontitis /

Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the

Oral microbiota in human systematic diseases Read More »

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Fasting /

Intermittent fasting (IF) has been studied for its effects on lifespan and lifespan as well as the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function Read More »

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

Diet and Exercise, Gut Microbiota /

Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota Read More »