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Clinical therapeutic effects of probiotics in patients with constipation associated with Parkinson disease

Constipation, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Constipation is the most predominant symptom of Parkinson disease (PD), preceding the occurrence of motor symptoms in some patients, leading to reduced quality of life (QOL). The general approaches for the treatment have some side effects, but probiotics are live or attenuated microorganisms attributed to ameliorating constipation effects. Moreover, as treatments are generally well tolerated and side […]

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Effect of Fiber and Fecal Microbiota Transplantation Donor on Recipient Mice Gut Microbiota

Fecal Transplants (FMT), Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Both fecal microbiota transplantation (FMT) and dietary fiber intervention were verified as effective ways to manipulate the gut microbiota, whereas little is known about the influence of the combined methods on gut microbiota. Here, we constructed “non-industrialized” and “industrialized” gut microbiota models to investigate the donor effect of FMT and diet effect in shaping the

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MISFOLDED α-SYN – FROM RELEASE AND UPTAKE TO CONTAGION OF ADJACENT CELL, ANY LINKS WITH GUT?

A-Synuclein, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

Alpha-synuclein(α-Syn) is an intracellular protein which is constantly synthesized and degraded underphysiological conditions. Abnormal aggregation of this protein within neuron is associated with severalneurodegenerative disorders, including Parkinson’s disease. Although the exact mechanism of initiation ofaggregation and misfolding pathway of a-Syn is yet to be discovered; it’s mechanism of spreading throughinterconnected neuronal networks has taken acompelling

MISFOLDED α-SYN – FROM RELEASE AND UPTAKE TO CONTAGION OF ADJACENT CELL, ANY LINKS WITH GUT? Read More »

Treating chronic diseases by regulating the gut microbiota

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Chronic diseases encompass a wide range of illnesses, ranging from cardiovascular and cerebrovascular diseases, metabolic syndromes to degenerative neurological disorders. Chronic diseases are responsible for most observed morbidity and mortality in the developed countries as well as in some developing countries. The gut microbiota and its metabolites have been associated with the onset and development

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Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Vitamins / Supplements / Nutraceuticals /

Berberine (BBR), an isoquinoline alkaloid, has been found in many plants, such as Coptis chinensis Franch. and Phellodendron chinense Schneid. Although BBR has a wide spectrum of pharmacological effects, its oral bioavailability is extremely low. In recent years, gut microbiota has emerged as a cynosure to understand the mechanisms of action of herbal compounds. Numerous studies have demonstrated that,

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Oral, nasal, and gut microbiota in Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Metabolites, Oral Microbiome /

Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease. The purpose of this study was to investigate the link between microbiota composition in important mucosal interfaces (oral, nasal, and intestinal) and PD. Sequencing was undertaken of the V4–V5 region of the 16S ribosomal RNA (rRNA) gene of the microbiome from the oral cavity,

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Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis

Probiotics, Prebiotics and Symbiotics /

According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a novel psychobiotic strain, improves motor function, depression, and anxiety behaviors. However, the psychobiotic effects and mechanisms of PS128 in Alzheimer’s disease (AD) remain to be explored. Objectives The goal of the current study was to

Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis Read More »

Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms best, while deep brain stimulation (DBS) is effective for advanced PD patients; however, side effects occur with the diminishing therapeutic window. Recently, Lactiplantibacillus plantarum PS128 (PS128) was found to elevate dopamine levels in rodent brains, suggesting its

Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease Read More »

Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontists

Periodontitis /

In conclusion, the present study revealed that quercetin ameliorated the oxidative damage and improved the antioxidative ability of PDLCs by activating the NRF2 signaling pathway in vitro and in vivo (Figure 7). In addition, quercetin could prevent alveolar bone absorption in periodontitis. Therefore, quercetin may be a potential therapeutic candidate for treatment of periodontitis. CLICK

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Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review, we discuss genetic and environmental risk factors for neurodegenerative diseases, summarize the communication among the components of the microbiota-gut-brain axis, and discuss the treatment strategy of fecal microbiota transplantation (FMT). FMT is a promising treatment

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