China

Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment

Gut Dysbiosis, Gut Microbiota, Metabolites, Mitochondria /

The search for therapeutic targets for Parkinson’s disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous system are incompletely understood. Multiple lines of evidence suggest that the gut microbiota participates […]

Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment Read More »

Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis

Gut Dysbiosis, Parkinson's Disease, Pre-PD /

Our meta-analysis identified a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO. These relationships were significantly different according to type of diagnostic test and geographic area. Therefore, we must pay close attention to enteric microorganisms to prevent nervous system diseases. CLICK TO REVIEW

Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis Read More »

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options

A-Synuclein, Biomarkers, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

We highlight recent discoveries and alterations of the gut microbiota in Parkinson’s disease, and highlight current mechanistic insights on the microbiota-gut-brain axis in disease pathophysiology. We discuss the interactions between production and transmission of α-synuclein and gut inflammation and neuroinflammation. In addition, we also draw attention to diet modification, use of probiotics and prebiotics and

The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options Read More »

Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Herbs & Spices, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

After in vitro digestion and anaerobic fermentation, both O. sinensis and C. militaris could modulate the gut microbiota composition through reducing the ratio of Firmicutes to Bacteroidetes. Moreover, this research demonstrated that O. sinensis had more positive effects on the intestinalhealth compared with C. militaris via decreasing the pH of gut environment, stimulating the production

Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris Read More »

Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease

A-Synuclein, Parkinson's Disease /

In this Review, we summarize the structure and physiological function of α-syn, and we further highlight the major PTMs (namely phosphorylation, ubiquitination, nitration, acetylation, truncation, SUMOylation, and O-GlcNAcylation) of α-syn and the effects of these modifications on α-syn aggregation, which may elucidate mechanisms for PD pathogenesis and lay a theoretical foundation for clinical treatment of

Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease Read More »

Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior

Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

The gut‐microbiota‐brain axis is the most important complex and bidirectional pathway between the gastrointestinal tract and the central nervous system. This study investigated the potential of microbe‐induced gut‐to‐brain signaling to modulate the effect of stress on depressive‐like behavior, intestinal barrier, and neuroinflammation. Result showed that fecal microbiota transplantation increased the consumption of sucrose solutions and

Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior Read More »

Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

WSBCW upregulated intestinal junction proteins, increased the abundance of Bifidobacterium genus, Desulfovibrio genus and inhibited Bacteroides fragillis group in the gut microbiota, increased intestinal villi lengths, and decreased blood levels of inflammatory cytokines. Our study provided preclinical evidence to verify the effectiveness of WSBCW in gastrointestinal health and elucidate mechanistic insights. The results warrant further investigations to evaluate the

Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation Read More »

Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Pre-PD, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial barrier function, and improved the microbiota in the colonic contents of weaned piglets, suggesting that niacin may be an effective way for weaned piglets to maintain the gut and overall health. CLICK TO REVIEW

Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation Read More »

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease

A-Synuclein, Biomarkers, Pre-PD /

This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to monitor disease progression. This review article describes the role of α-Syn in PD and how it could potentially be used as a biomarker for PD. Also, preclinical and clinical investigations encompassing genetics, immunology, fluid and

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease Read More »

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Pre-PD /

These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to gut microbiome homeostasis through multiple manipulations including immune modulation, inflammation restriction as well as epithelial barrier maintenance, thus finally determine the fate of UC progression and give implications for functional food development for prevention and

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis Read More »