Czech Republic

Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing [1,2,3]. The increased morbidity of human populations makes them more vulnerable to additional burdens, including infectious diseases. For example, the mortality rate of diabetics infected with the original variant of the SARS Co-2 virus was about twice that of the general […]

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Increased Transferrin Sialylation Predicts Phenoconversion in
Isolated REM Sleep Behavior Disorder

A-Synuclein, Gut Dysbiosis, iRBD /

Sialic acid–protein interactions are involved in regulating central nervous systemimmunity; therefore, derangements in sialylation could beinvolved in neurodegeneration. Decreased serum CDTadj is associatedwith substantia nigra degeneration in synucleinopathies.iRBD patients with low CDTadj are more likely tophenoconvert to manifest disease. CLICK TO REVIEW

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An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population

Ayahuasca, Breath /

Background Holotropic breathwork (Grof ® Breathwork), was developed by Stanislav Grof and Christina Grof as a ‘non-drug’ alternative technique to evoke altered states of consciousness (ASC). Interestingly, although HBW has been anecdotally reported to evoke experiences and mental health effects corresponding to those of psychedelic substances, the scientific literature on the matter is scarce. Aims

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Systematic video-analysis of motor events during REM sleep in idiopathic REM sleep behavior disorder, follow-up and DAT-SPECT

Biomarkers, iRBD /

Patients with higher amounts of violent Motor Events had a greater risk of phenoconversion; therefore, their role as a predictor should be considered. Additionally, ME were associated with nigrostriatal degeneration, according to DAT-SPECT. These findings indicate that the degree of the clinical severity of motor manifestations in iRBD reflects the severity of the disease. CLICK

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PREMOTOR PARKINSON’S DISEASE: OVERVIEW OF CLINICAL SYMPTOMS AND CURRENT DIAGNOSTIC METHODS

Biomarkers, iRBD, Pre-PD, Symptoms / Diagnosis /

The best known premotor symptoms include hyposmia, REM sleep behavior disorder (RBD), constipation, and depression; other symptoms are excessive daytime somnolence, orthostatic hypotension and symptomatic hypotension, erectile or urinary dysfunction, musculoskeletal symptoms, pain, and global cognitive deficit. In this review, we summarize currently available diagnostic methods for these symptoms. We also briefly summarize neuroimaging, polyneuropathy,

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Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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