The gut microbiome exerts a fundamental role in host physiology. Extrinsic factors such as lifestyle and diet are widely recognized as the main drivers of gut microbiota composition [1, 2]. While drinking water is among the food items consumed in the largest amount, little is known about its potential impact on gut microbiota structures [3-5]. Objective: We explored […]
Uncontrolled oxidative stress, reported in Salmonella and HIV infections, colorectal cancer or severe acute malnutrition, has been associated with anaerobic gut microbiome alteration, impaired butyrate production, mucosal immunity dysregulation and disruption of host-bacterial mutualism. However, the role of major antioxidant molecules in the human body, such as glutathione, ascorbic acid and uric acid, has been neglected in
Cardiovascular diseases, chronic obstructive pulmonary diseases, diabetes, rheumatoid arthritis, and cancer are the most common noncommunicable diseases (NCDs). These NCDs share risk factors with periodontal disease (PD), a preventable risk factor linked to lifestyle. The discussion regarding the association between these chronic diseases is more complex. There is still a significant knowledge gap particularly of
Care management of Parkinson’s disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Earlier detection of PD therefore represents a key step for developing therapies able to delay or slow down its progression. From our translational study, which included 3 animal models
Gait parameters and a pretrained statistical model can robustly distinguish participants with iRBD from HCs and patients with PD. This could be used to screen subjects with future synucleinopathies in the general population and to identify a conversion threshold to PD. CLICK TO REVIEW
Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society CLICK TO REVIEW
Dairy Intake and Parkinson’s Disease: A Mendelian Randomization Study Read More »
There is increasing evidence for the important role of gut microbiota (GMB) in the development and progression of neurologic pathologies. Some studies have shown that modifying the microbiome profile can confer benefits to patients. Mild traumatic brain injury (mTBI) is a common occurrence in the general population. Although most patients recover, in a minority, disabling
Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However, whetherthe assay can be used as a robust, quantitative measure to monitor disease progression, stratifydifferent synucleinopathies and predict disease conversion in patients with idiopathic REMsleep behaviour disorder remains undetermined. The aim of this study was
Cellular quality control systems have gained much attention in recent decades. Amongthese, autophagy is a natural self-preservation mechanism that continuously eliminates toxic cellularcomponents and acts as an anti-ageing process. It is vital for cell survival and to preserve homeostasis.Several cell-type-dependent canonical or non-canonical autophagy pathways have been reportedshowing varying degrees of selectivity with regard to
Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease Read More »