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A novel multi-target strategy to attenuate the progression of Parkinson’s disease by diamine hybrid AGE/ALE inhibitor

A-Synuclein, Parkinson's Disease, Pre-PD /

Instead of a conventional ‘one-drug-one-target approach’, this article presents a novel multi-target approach with a concept of trapping simultaneously as many detrimental factors as possible involved in the progression of Parkinson’s disease. These factors include reactive carbonyl species, reactive oxygen species, Fe3+/Cu2+ and ortho-quinones (o-quinone), in particular. Different from the known multi-target strategies for Parkinson’s disease, […]

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Interactions between the microbiota and enteric nervous system during gut-brain disorders

ENS, Gut Microbiota /

The ENS, which is known as the “second brain”, could be under the direct or indirect influence of the gut microbiota and its released factors (short-chain fatty acids, neurotransmitters, gaseous factors, etc.). Thus, in addition to their actions on tissue (adipose tissue, liver, brain, etc.), microbes can have an impact on local ENS activity. This potential

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Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

A-Synuclein, Gut-Brain axis /

. This study does not support the hypothesis of a transmission of a-synuclein pathology through the vagus nerve and the dorsal motor nucleus of the vagus. Instead, our results suggest a possible systemic mechanism in which the general circulation would act as a route for long-distance bidirectional transmission of endogenous a-synuclein between the enteric and

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Iron homeostasis in host and gut bacteria – a complex interrelationship

Gut Microbiota, Iron /

Iron deficiency is the most frequent nutritional deficiency in the world with an estimated 1.4 billion people affected. The usual way to fight iron deficiency is iron fortification, but this approach is not always effective and can have undesirable side effects including an increase in the growth and virulence of gut bacterial pathogens responsible for

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