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A blood marker for Parkinson’s Disease: Neuronal exosome-derived α-synuclein

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD, Symptoms / Diagnosis /

To date, no reliable clinically applicable biomarker has been established for Parkinson’s disease (PD). Our results indicate that a long hoped blood test for Parkinson’s disease may be realized. We here assess the potential of pathological α-synuclein originating from neuron-derived exosomes from blood plasma as a possible biomarker. Following the isolation of neuron-derived exosomes from […]

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Parkinson’s is announced long before the diagnosis

Constipation, iRBD, Olfactory, Sleep /

Parkinson’s disease is a progressive disease of the brain caused by the death of special nerve cells. The disease is characterized by movement disorders such as slowing movements, stiffness of the muscles, tremors or specific changes in the gait pattern. Often there can be many years before these typical symptoms permit a diagnosis of Parkinson’s disease. These can

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Dietary restrictions modulate the gut microbiota: Implications for health and disease

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

The data suggest that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

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Microbiota-derived short chain fatty acids modulate microglia and promote Ab plaque deposition

Gut Microbiota, Parkinson's Disease, Short Chain Fatty Acids /

Despite increased microglial recruitment to Ab plaques upon SCFA supplementation, microglia contained less intracellular Ab. Taken together, our results demonstrate that microbiota-derived SCFA are critical mediators along the gut-brain axis which promote Ab deposition likely via modulation of the microglial phenotype. CLICK TO REVIEW

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Complications following REM sleep behavior disorder

iRBD, Parkinson's Disease, Pre-PD /

REM sleep behavior disorder (RBD) is gaining increasing attention as important prodromal marker for the development of neurodegenerative disorders such as Parkinson’s Disease. However, the clinical relevance of this disorder and its association with other prodromal markers is often underestimated in clinical routine. We here report a case of severe clinical complications following extensive nocturnal

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Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

A-Synuclein, Gut-Brain axis /

. This study does not support the hypothesis of a transmission of a-synuclein pathology through the vagus nerve and the dorsal motor nucleus of the vagus. Instead, our results suggest a possible systemic mechanism in which the general circulation would act as a route for long-distance bidirectional transmission of endogenous a-synuclein between the enteric and

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Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease

Iron, Parkinson's Disease, Pre-PD /

The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+, implicating a critical increase in the labile iron pool. Indeed, neuromelanin is characterized by a significantly higher loading of iron including most probable the occupancy of low-affinity iron binding sites. Quantitative trace element analysis is

Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease Read More »

Dietary restrictions modulate the gut microbiota: Implications for health and disease

Biomarkers, Butyrate, Diet and Exercise, Gut Permeability / Leaky Gut, Gut-Brain axis /

The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression of several diseases such as obesity, diabetes, neurological diseases or inflammatory bowel disease. Finally, the relevance of the findings for clinical practice is evaluated and approaches for future research are proposed. CLICK TO REVIEW

Dietary restrictions modulate the gut microbiota: Implications for health and disease Read More »