Germany

The microbiota–microglia axis in central nervous system disorders

Biomarkers, Butyrate, Gut Microbiota, Pre-PD, Short Chain Fatty Acids /

Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids (SCFAs) or aryl hydrocarbon receptor (AhR) ligands. Thereby, the gut microorganisms are deemed to influence numerous CNS diseases mediated by microglia.In this review, we summarize recent findings of the interaction between the host microbiota and […]

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MDS research criteria for prodromal Parkinson’s disease

Biomarkers, Pre-PD /

 This diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker testing. In order to be included, diagnostic markers had to have prospective evidence documenting ability to predict clinical PD. They include motor and nonmotor clinical symptoms, clinical signs, and ancillary diagnostic tests. These criteria represent

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