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Identification of alpha-Synuclein Disaggregator from Camellia sp. Insight of Molecular Docking and Molecular Dynamics Simulations

A-Synuclein, Diet and Exercise /

Misfolded protein formation and aggregation are the central hallmarks for various neurodegenerative disorders. When it comes to Parkinson’s disease (PD), alpha-synuclein (α-syn) is the culprit protein. The presence of α-syn protein in lewy bodies and lewy neurites confirmed its presence in the occurrence of PD. The protein is natively present in the soluble monomeric forms, […]

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Molecular Docking Studies of Secondary Metabolites against Sequestosome-1 to Treat Parkinson Disease

Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is one of the major progressive neurological disorders. It occurs due to a low level of achemical substance in the brain known as Dopamine, which controls the muscle movements of the body. In many cases, PDoccurs due to a low level of dopamine. PD generally appears in persons between the ages of

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A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis

Oral Microbiome, Periodontitis /

Periodontal disease (PDD) and rheumatoid arthritis (RMA) share comparative pathophysiological pathways like ongoingaggravation with resorption of the proximal bone in immunologically delicate hosts; However, PDD has a notable bacteriological etiology, and the cause of RMA remains unknown. According to some reports, an infectious agent in a vulnerable host may be the cause of RMA and

A Review of Literature on the Relationship Between
Oral Microbiota and Rheumatoid Arthritis Read More »

Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior of brain. Dysbiosis or dysbacteriosis is a condition of microbial imbalance inside the intestinal microbiome. It has been associated with disorders of intestinal and extra‐intestinal such as inflammatory bowel disease and other multiple diseases like

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The role of probiotics in nutritional health: probiotics as nutribiotics

Biomarkers, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health. A wide variety of microorganisms shape this gut microbiota, which preserves health with the modulation of the immune system, enhancement of the nutrients absorption, or the protection against pathogens’ colonization. The disruption of this microenvironment

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Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Autophagy, Gut Dysbiosis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut microbiota and the brain via immune, circulatory and neural pathways, termed the Gut-Brain Axis (GBA). Alterations in gut microbiota composition, such as seen with an increased number of pathobionts

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle Read More »

Plant derived bioactive compounds and their potential to enhance adult neurogenesis

Anti-oxidants, Herbs & Spices, Parkinson's Disease, Pre-PD /

Self-renewal and proliferation of neural progenitor cells occur throughout humans’ lives. However, aging, stress, and degenerative diseases can hinder or stop the process. If you can accelerate neurogenesis in adults, this is a promising way to recover from neurodegeneration and cognitive impairments. As the demand for a safer and natural therapeutic product has increased over

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Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients

endondonics, Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD /

Objective and background The objectives were to compare periodontal status between subjects with and without Parkinson’s disease (PKD) to determine the influence of PKD on periodontal disease. This study was conducted to evaluate the relationship of periodontal status with severity of PKD. Conclusion There is a need for dental care and encouragement to use plaque

Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson’s disease patients Read More »

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Gut Dysbiosis /

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut microbiota and the brain via immune, circulatory and neural pathways, termed the Gut-Brain Axis (GBA). Alterations in gut microbiota composition, such as seen with an

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle Read More »