Microbiota-targeted interventions such as personalized diet, probiotics, or fecal microbiota transplantation (FMT) might represent a potential therapeutic option for AD. This review article discusses the procedure of FMT and its possible side effects on the recipient’s body. In addition, we review the role of FMT in the context of its application in various nervous system-related […]
Progressive loss of functional neurons is typically characterized as neurodegeneration. This is particularly pronounced during aging and results in debilitating conditions such as Parkinson’s disease and Alzheimer’s disease. Symptoms appear typically after 70–80% neuronal loss, resulting in irreversible damage. Several drugs have been clinically approved but they only alleviate symptoms and additionally lead to undesirable
Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW
Neurological disorders associated with impaired gut microbiota Read More »
Both animal and human studies evaluating the role of gut dysbiosis on various neurological and neurosurgical diseases, published in peer-reviewed journals, were reviewed. Current studies do not provide conclusive evidence of a direct origin of CNS disorders from gut dysbiosis, but a possible modulatory role of gut microbiota in certain neurological disorders has been implicated.
Does modern research validate the ancient wisdom of gut flora and brain connection? Read More »
The current review summarizes the popular nutraceuticals showing different effects (anti‐inflammatory, antioxidant, neuro‐protectant, mitochondrial homeostasis, neurogenesis promotion,and autophagy regulation) on vital molecular mechanisms involved in NDs, which can beconsidered as complementary therapy to first‐line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti‐oxidative and
Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and Huntington’s disease (HD). Consequently, the analysis indicates that polyphenol beneficial effects on human brain activity and this review describe these implications by discussing the latest mechanistic hypothesis. CLICK TO
Natural polyphenols in central nervous system disorders Read More »
There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to initiate the free radical formation and affecting the basal ganglia signaling. In this review, we explored how these metals affect brain physiology and their roles in the accumulation of toxic proteins (α-synuclein and Lewy bodies).
Hence, this review will mainly focus on analysing the basic components of the gut that might be responsible for aggravating lewy pathology, the mediator(s) responsible for transmission of PD pathology from gut to brain and the important role of trehalose in ameliorating gut dysbiosis related PD complications that would eventually pave the way for therapeutic
Hence, autophagy modulation might provide some interesting cues for the treatment of PD. Additionally, Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective in various neurodegenerative conditions possibly via mediation of autophagy. CLICK TO REVIEW
Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease Read More »
Nevertheless, the scientific literature is overflowing with the remarkable observations supporting the role of dysbiosis in PD. Lack of specificity to differentially diagnose PD with non-PD or PD-plus syndrome, to identify highly precise drug targets and to develop therapeutic stratagems to encounter the disease on the basis of this approach, causes us to be open-minded
Is Gut Dysbiosis an Epicenter of Parkinson’s Disease? Read More »