Risk and protective factors of PD development may influence PD clinical features. This finding may represent the first step in the development of new preventive approaches able to delay disease onset and mitigate the extent of clinical manifestations. CLICK TO REVIEW
The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson’s disease and other neurological disorders with a shared
Parkinson’s Disease: A Prionopathy? Read More »
Importance of a healthy lifestyle in maintaining the population’s well-being and health,especially in terms of balanced nutrition, is well known. Food choice of and dieting habits couldimpact disease management, which is especially true for Parkinson’s disease (PD). However, nowadays, it is not that simple to maintain a balance in nutrition, and the idea of a
Environmental exposures to agrochemicals and nutritional factors may be associated with Parkinson’s Disease (PD). None of the studies to date has examined the combined effects of diet and agricultural chemical exposure together. To address these research gaps, we aimed to assess the association of nutritional factors and agrochemical exposure with the risk of PD. A
This chapter explores the role of the gut-brain axis, ketogenic diet, and cow’s milk allergy onepileptic seizures, with a special focus on childhood. Milk nutrition is particularly relevant fornormal growth and health in childhood; however, some studies report an association betweencow’s milk allergy and epileptic events. It is necessary to clarify the role of proteinpolymorphisms
The Role of Milk Nutrition and Ketogenic Diet in Epileptic
Disorders Read More »
The endocannabinoid system is a complex lipid signaling network that has evolved tobe a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerousprocesses has rendered it a very suitable target for pharmacological studies regarding metabolicsyndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have beenfound in a large variety of foods, most of
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eyemovements sleep behavior disorder (iRBD) were compared with 17 patientswith RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated a-synuclein depositsand whole-night video-polysomnography. Skin biopsy was positive for phosphorylated a-synuclein deposits in 86.7% of iRBD patients and in none
Biomarkers for REM sleep behavior disorder in idiopathic
and narcoleptic patients Read More »
: Gut microbiota encompasses a wide variety of commensal microorganisms consisting oftrillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host,and related metabolites have profound effects on human health. In this respect, gut microbiota playsa pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolitesinclude the short
Gut Microbiota and Short Chain Fatty Acids: Implications in
Glucose Homeostasis Read More »
Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial
Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease Read More »
Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Ofnote, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of theintestinal disturbances in PD. In this context, although several review articles have pooled together