Italy

The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells

Gut Dysbiosis, Gut-Brain axis /

Much evidence has accumulated over the past decade in favor of a significant association between dysbiosis, neuroinflammation and neurodegeneration. Presently, the pathogenetic mechanisms triggered by molecules produced by the altered microbiota, also responsible for the onset and evolution of Alzheimer Disease will be described. Our attention will be focused on the role of astrocytes and […]

The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells Read More »

Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders

Anti-oxidants, Parkinson's Disease /

This review will focus on the most promising marine drugs’ neuro-protective potential for neuro-degenerative disorders, such as Parkinson’s and Alzheimer’s diseases. We will describe these marine compounds’ potential as adjuvant therapies for neuro-degenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties. CLICK TO REVIEW

Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders Read More »

Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota /

The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neu-roprotective effects, particularly in the Lachnospiraceae family and key members,such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, andBlautia. The direct evalua-tion of fecal metabolites revealed changes in several classes of metabolites. Changeswere seen in lipids (linoleic acid, oleic acid,

Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease Read More »

Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes

Gut Microbiota, Gut-Brain axis, Pre-PD, Symptoms / Diagnosis /

We hypothesize that themicrobiota/metabolome enterotypes associated to non-TD subtypes may favor the developmentof gut inflammatory environment and gastrointestinal dysfunctions and therefore a more severeα-synucleinopathy. This study adds important information to PD pathogenesis and emphasizes thepotential pathophysiological link between gut microbiota/metabolites and PD motor subtypes(PDF) Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and

Clinical Phenotypes of Parkinson’s Disease Associate with Distinct Gut Microbiota and Metabolome Enterotypes Read More »

Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols

Diet and Exercise, Polyphenols, Vitamins / Supplements / Nutraceuticals /

Neurodegenerative diseases are becoming a big challenge for modern society. Neurodegenerative disorders strongly impact on patient and their caregivers. Moreover, since the population is becoming older, these pathologies will deeply influence medical and socio-economic conditions in the next years. CLICK TO REVIEW

Novel perspectives for neurodegeneration prevention: effects of bioactive polyphenols Read More »

The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?

Probiotics, Prebiotics and Symbiotics /

This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy, confirming that gut microbiota modulation influences different pro-survival pathways. Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. CLICK TO REVIEW

The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease? Read More »