Growing evidences show that gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD) and the gut-brain axis can be promising target for the development of the therapeutic strategies for PD. Acupuncture has been used to improve brain functions and inflammation in neurological disorders such as PD, and to recover the gastrointestinal dysfunctions in […]
Microbial dysbiosis in the gut is associated withhuman diseases, and variations in mucus alter gut microbiota.Therefore, we explored the effects of mucin on the gut microbiotausing a community of 19 synthetic gut microbial species. Cultivationof these species in modified Gifu anaerobic medium (GAM)supplemented with mucin before synthetic community assemblyfacilitated substantial growth of the Bacteroides, Akkermansia,and
: The microbiome has emerged as a key player contributing significantly to the humanphysiology over the past decades. The potential microbial niche is largely unexplored in the contextof exercise enhancing capacity and the related mitochondrial functions. Physical exercise can influence the gut microbiota composition and diversity, whereas a sedentary lifestyle in association withdysbiosis can lead
The DTI-ALPS index was significantly lower in patients with iRBD than in healthy controls, indicating the presence of glymphatic-system dysfunction in patients with iRBD. Our study also suggests that the DTI-ALPS index could serve as a biomarker for evaluating glymphatic-system function in neurological disorders. CLICK TO REVIEW
Glymphatic dysfunction in isolated REM sleep behavior disorder Read More »
Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD
The gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of evidence indicates that the microbiome exerts significant effects on immune cells and CNS cells. These effects frequently result in the suppression or exacerbation of inflammatory responses, the latter of which can lead to severe tissue
Regulation of common neurological disorders by gut microbial metabolites Read More »
Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the development of therapeutics targeting amyloid-β (Aβ) and tau, principal proteins inducing pathology in AD, suggest a paradigm shift towards the development of new therapeutic targets. The gram-negative bacteria and lipopolysaccharides (LPS) are attractive new targets
Our results suggest that vagotomy has protective effects onnigrostriatal dopaminergic degeneration and disease progression insubsequent Parkinson’s disease, but may be unfavorable for cognitiveperformance. The neuroprotective effect of vagotomy could be largelymediated by blocking the spread of α-synuclein from the gut to the brain,and the modulation of inflammatory response might also contribute tosome extent. CLICK TO
Effect of vagotomy on modulation of dopaminergic neurons in Parkinson’s disease Read More »
Our findings indicate that when cognition is reduced to MCI levels in iRBD patients, the attention network, especially the alerting component, is impaired. The attention network and cognition, on the other hand, can be preserved in iRBD patients due to the compensatory mechanism. CLICK TO REVIEW Keywords REM sleep behavior disorder, Event-related potentials, Attention network
The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system
Gut Microbiome and Alzheimer’s Disease Read More »