metabolites

The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Biomarkers, Butyrate, Gut Microbiota, Gut-Brain axis, Metabolites, Short Chain Fatty Acids /

We found significantly altered SCFA levels in patients with autism spectrum disorder (ASD), affective disorders, multiple sclerosis (MS) and Parkinson’s disease (PD). NonSCFAs yielded less significantly distinct changes in faecal levels of patients and healthy controls, with the majority of findings were derived from urinary and blood samples. Preclinical studies have implicated different bacterial metabolites […]

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Gut microbial ecosystem in Parkinson’s disease: New clinico-biological insights from multi-omics

Biomarkers, Butyrate, Gut Microbiota, Metabolites /

Gut microbial function is altered in PD, characterized by differentially abundant metabolic features that provide important biological insights into gut-brain pathophysiology. Their clinical relevance further supports a role for microbial-metabolites as potential targets for the development of new biomarkers and therapies in PD. CLICK TO REVIEW

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Why Researchers Look to Gut Microbial Metabolites in Parkinson’s Disease

Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Short Chain Fatty Acids, Symptoms / Diagnosis /

Findings highlight significant differences in the fecal microbiome and metabolome in patients with Parkinson’s disease and control subjects, demonstrating an important connection between the brain and gut that could influence the disease process and progression. CLICK TO REVIEW

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Neuroprotective potential of cinnamon and its metabolites in Parkinson’s disease: Mechanistic insights, limitations, and novel therapeutic opportunities

Gut Microbiota, Parkinson's Disease /

 In addition, in vitro and in vivo studies have shown that cinnamon extracts may affect the oligomerization process and aggregation of α‐synuclein. Herein, we discuss recent evidence on the novel therapeutic opportunities of this phytochemical against PD, indicating additional mechanistic aspects that should be explored, and potential obstacles/limitations that need to be overcome, for its

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Gut Microbiota and Metabolome Alterations Associated with Parkinson’s Disease

Butyrate, Gut Dysbiosis, Gut Microbiota /

The most significant changes within the Parkinson’s disease group highlighted a reduction in bacterial taxa, which are linked to anti-inflammatory/neu-roprotective effects, particularly in the Lachnospiraceae family and key members,such as Butyrivibrio, Pseudobutyrivibrio, Coprococcus, andBlautia. The direct evalua-tion of fecal metabolites revealed changes in several classes of metabolites. Changeswere seen in lipids (linoleic acid, oleic acid,

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Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health

Butyrate, Diet and Exercise, Gut Microbiota /

Given the tremendous amount of evidence linking neuroinflammation with neural dysfunction, it is no surprise that the Western diet has been implicated in the development of many diseases and disorders of the brain, including memory impairments, neurodegenerative disorders, and depression. In this review, we discuss each of these concepts to understand how what we eat

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