mitochondria

Neurotoxins that cause parkinsonism and the search for analogues in the environment

Biomarkers /

Through the tragic misadventures described in Addicts,the parkinsonism-inducing neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) was discovered. It hasbeen one of the most important tools in generating animalmodels to study Parkinson’s disease. Studies of how it killsdopaminergic neurons have revealed their Achilles’ heel,mitochondria, the power plants of cells. Mitochondriaprovide cells with adenosine triphosphate, the chemicalenergy molecule that the cells’ […]

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Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?

Mitochondria /

Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic needs of the cell. There are multiple data suggesting that disturbed mitochondrial homeostasis can lead to Parkinson’s disease (PD) development. 2-methoxyestradiol (2-ME), metabolite of 17β-estradiol (E2) and potential anticancer agent, was demonstrated to inhibit cell

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The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

Autophagy, Mitochondria, Uncategorized /

The increased activity of mPTP in aging turns autophagy/mitophagy into a destructive process leading to cell aging and death. Several drugs and lifestyle modifications that enhance healthspan and lifespan enhance autophagy and inhibit the activation of mPTP. Therefore, elucidating the intricate connections between pathways that activate and inhibit mPTP, in the context of aging and

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How microcompetition with latent viruses can cause α synuclein aggregation, mitochondrial dysfunction, and eventually Parkinson’s disease

A-Synuclein, Mitochondria, Viral / Bacterial Infections /

The cause of most Parkinson’s disease cases is unknown. However, it is well documented that mitochondrial dysfunction and misfolded α synuclein aggregation are important cellular abnormalities associated with the disease. In this paper, we use the microcompetition model to show how latent viruses, which infect the central and peripheral nervous systems, can cause the observed mitochondrial dysfunction

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Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . .

A-Synuclein, Gut-Brain axis, Mitochondria /

ABSTRACT: Here, we give an overview of the progress that has been made over the past four decades in our understanding of this disorder. We review the role of mitochondria, environmental toxicants, alpha-synuclein and neuroinflammation in the development of PD. We also discuss more recent data from genetics, which strongly support the endosomal-lysosomal pathways and

Pathophysiology of Parkinson’s disease:
Mitochondria, alpha-synuclein and much more. . . Read More »

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

Diet and Exercise, Library, Mitochondria /

We present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in these diseases and highlight recent advances in novel therapeutic strategies targeting neuronal bioenergetics as potential approach for treating these diseases. CLICK TO REVIEW

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