Alzheimer’s disease (AD) is a global public health priority as with aging populations, its prevalence is expected to rise even further in the future. The brain and gut are in close communication through immunological, nervous and hormonal routes, and therefore, probiotics are examined as an option to influence AD hallmarks, such as plaques, tangles, and […]
The gut microbiome is associated with diverse diseases1,2,3, but a universal signature of a healthy or unhealthy microbiome has not been identified, and there is a need to understand how genetics, exposome, lifestyle and diet shape the microbiome in health and disease. Here we profiled bacterial composition, function, antibiotic resistance and virulence factors in the
Environmental factors shaping the gut microbiome in a Dutch population Read More »
SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson’s disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the above mentioned
Nocturnal Teeth Grinding Linked With Incidence of Other Sleep-Related Disorders Read More »
With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF)
The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch
Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study Read More »
The importance of diet and the gut-brain axis for brain health and cognitive function isincreasingly acknowledged. Dietary interventions are tested for their potential to prevent and/ortreat brain disorders. Intermittent fasting (IF), the abstinence or strong limitation of calories for 12to 48 hours, alternated with periods of regular food intake, has shown promising results on neurobiological
The Effects of Intermittent Fasting on Brain and Cognitive Function Read More »
Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin
Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin may aid in monitoring a leaky gut and detecting individuals at risk for developing chronic metabolic diseases. CLICK TO REVIEW
In this work, we investigated the ability of amyloid fibrils derived from two food proteins to heterologously seed the aggregation of the PD-related aSyn protein. While β-lactoglobulin amyloid fibril seeds were not able to induce aSyn aggregation, we identified a fibril surface–mediated nucleation mechanism for the seeding of aSyn aggregation by hen egg white lysozyme
Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins Read More »
The presence of olfactory dysfunction conveys a considerably elevated risk of incident PD, likely more in studies with a higher proportion of women, older individuals or short follow-up duration. Individual patient data are warranted to confirm these findings and to yield subgroup-specific risk estimates of other common markers to refine prodromal PD criteria. CLICK TO