neurodegeneration

Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Ayahuasca, Parkinson's Disease, Pre-PD /

Psychedelics are increasingly being recognized for their potential to treat a wide range of braindisorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder.Their broad therapeutic potential might result from an ability to rescue cortical atrophy common tomany neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor geneexpression, activating neuronal growth and survival mechanisms, and […]

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Metabolic Strategies in Healthcare: A New Era

Diet and Exercise, Fasting, Mitochondria /

Modern healthcare systems are founded on a disease-centric paradigm, which has conferred manynotable successes against infectious disorders in the past. However, today’s leading causes of death are dominatedby non-infectious “lifestyle” disorders, broadly represented by the metabolic syndrome, atherosclerosis, cancer,and neurodegeneration. Our disease-centric paradigm regards these disorders as distinct disease processes,caused and driven by disease targets

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Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Gut Dysbiosis, Gut Microbiota, Short Chain Fatty Acids /

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal immune cells of this organ. Microglial features are strongly dependent on environmental cues such as commensal microbiota. Gut bacteria are known to continuously modulate microglia maturation and function by the production of short-chain fatty acids (SCFAs). However, the precise mechanism of this crosstalk is unknown. Here we determined that

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The role of the host microbiome in autism and neurodegenerative disorders and effect of epigenetic procedures in the brain functions

Gut Dysbiosis, Gut-Brain axis, Vagal Nerve /

Autism Spectrum Disorder (ASD) is a severe neurological/neurodegenerative syndrome that results in cognitive and communication disorders. The degree of dysbiosis is related to the severity of ASD signs. The gut is conferred with a variety of sensory receptors that cooperate with effector systems including the endocrine, nervous and gut immune systems of the intestine. Gut

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Gut Microbiome and Alzheimer’s Disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly growing number of scientific reports highlight important roles played by peripheral infections and intestinal bacterial flora in pathological and physiological functions involving the microbiome-intestine-brain axis. The microbiome controls basic aspects of the central nervous system

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Parkinson’s disease outside the brain: targeting the autonomic nervous system

A-Synuclein, Parkinson's Disease /

Patients with Parkinson’s disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even precede motor deficits. This dysregulation might reflect early pathology and therefore could be targeted for the development of prodromal or diagnostic biomarkers. Only a few objective clinical tests assess disease progression and are used to

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Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Gut Dysbiosis /

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut microbiota and the brain via immune, circulatory and neural pathways, termed the Gut-Brain Axis (GBA). Alterations in gut microbiota composition, such as seen with an

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Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate

Butyrate, Gut Dysbiosis, Hydrogen /

Further experiments demonstrated that the beneficial effect of butyrate depended on the bacteria that colonized the gut and that this protective effect required SKN-1/Nrf2 and DAF-16/FOXO transcription factors. We also found that bacteria-derived protein aggregates contribute to the observed disruption of host proteostasis. Together, these results reveal the significance of enteric infection and gut dysbiosis

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The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells

Gut Dysbiosis, Gut-Brain axis /

Much evidence has accumulated over the past decade in favor of a significant association between dysbiosis, neuroinflammation and neurodegeneration. Presently, the pathogenetic mechanisms triggered by molecules produced by the altered microbiota, also responsible for the onset and evolution of Alzheimer Disease will be described. Our attention will be focused on the role of astrocytes and

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Diet-Microbiota-Brain Axis in Alzheimer’s Disease

Gut Microbiota /

A strong association exists between lifestyle factors and AD prevalence wherein unhealthy dietary factors have been linked to neurodegeneration. Specific prudent dietary patterns might help in preventing or delaying AD progression by affecting β-amyloid production and tau processing and regulating AD-associated inflammation, metabolism and oxidative stress, plausibly via modulating gut microbiota. CLICK TO REVIEW

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