Neuroprotective

Predictors of RBD progression and conversion to synucleinopathies

Biomarkers, iRBD /

There is a variety of potential biomarkers for monitoring disease progression and predicting iRBD conversion into synucleinopathies. A combined multimodal biomarker model could offer a more sensitive and specific tool. Further longitudinal studies are warranted to iRBD as a high-risk population for early neuroprotective interventions and disease-modifying therapies. CLICK TO REVIEW

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Effects of Intermittent Fasting On Cognition and
Neurodegeneration

Fasting, Parkinson's Disease /

Intermittent fasting (IF) can facilitate neurodegenerative, neuroadaptive and neuroprotective processes leading toprofound effects on cognition and dementias. The impact that IF has on the central nervous system is still not fullyknown. Several factors come into likely effect including changes in energy metabolism, oxidative damage, insulinsensitivity, inflammation, and functional changes related to various neurotransmitters and hormones.

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Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Parkinson’s disease (PD) is a neurodegenerative disordercharacterized by a progressive loss of dopaminergic neu-rons in the substantia nigra (SN). The present study wasdesigned to examine the therapeutic effect of hydrogensulfide (H2S, a novel biological gas) on PD. The endoge-nous H2S level was markedly reduced in the SN in a6-hydroxydopamine (6-OHDA)-induced PD rat model. Sys-temic administration

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Supplementation of regular diet with medium-chain triglycerides for neuroprotective effects

Diet and Exercise, Short Chain Fatty Acids /

This review summarizes currently available research on the effects and revealed mechanisms of using MCTs as a supplement to standard feed/diet without concomitant reduction of carbohydrate intake, highlighting open questions and potential considerations.

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Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease

Autophagy, Parkinson's Disease, Pre-PD /

Hence, autophagy modulation might provide some interesting cues for the treatment of PD. Additionally, Fibroblast growth factor 21 (FGF21) which is known for its role as a potent regulator of glucose and energy metabolism has also proved to be neuroprotective in various neurodegenerative conditions possibly via mediation of autophagy. CLICK TO REVIEW

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