research

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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Relationship between risk and protective factors and clinical features of Parkinson’s disease

Biomarkers, Parkinson's Disease, Pre-PD /

Risk and protective factors of PD development may influence PD clinical features. This finding may represent the first step in the development of new preventive approaches able to delay disease onset and mitigate the extent of clinical manifestations. CLICK TO REVIEW

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Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway

Biomarkers, Mitochondria, Parkinson's Disease, Pre-PD /

Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson’s disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The aim of this study was to investigate the protective mechanisms of HBOT on neurons and motor function in

Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway Read More »

Proof of Concept Study of Prebiotics to Modulate Gut Microbiome in Parkinson’s Disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Consumption of a novel prebiotic mixture rapidly impacted the intestinal microbiota (10 days), reduced the abundance of pro-inflammatory bacteria and promoted the growth of beneficial SCFA-producing bacteria. In addition, prebiotic consumption increased plasma SCFA levels, and improved markers of intestinal barrier integrity and brain health. This proof-of-concept study provides evidence for the importance of intestinal

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Neuroimaging evidence of glymphatic system dysfunction in possible REM sleep behavior disorder and Parkinson’s disease

A-Synuclein, Gut-Brain axis, iRBD /

Alpha-synucleinopathy is postulated to be central to both idiopathic rapid eye movement sleep behaviour disorder (iRBD) and Parkinson’s disease (PD). Growing evidence suggests an association between the diminished clearance of α-synuclein and glymphatic system dysfunction. However, evidence accumulating primarily based on clinical data to support glymphatic system dysfunction in patients with iRBD and PD is

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Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

Growing evidences show that gut microbiota is associated with the pathogenesis of Parkinson’s disease (PD) and the gut-brain axis can be promising target for the development of the therapeutic strategies for PD. Acupuncture has been used to improve brain functions and inflammation in neurological disorders such as PD, and to recover the gastrointestinal dysfunctions in

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Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway

endondonics, Periodontitis, Root Canal /

There are many patients in general practice with health complaints that cannot be medically explained. Some of these patients attribute their health complaints to dental amalgam restorations. This study examined the cost-effectiveness of the removal of amalgam restorations in patients with medically unexplained physical symptoms (MUPS) attributed to amalgam fillings compared to usual care, based

Is amalgam removal in patients with medically unexplained physical symptoms cost-effective? A prospective cohort and decision modelling study in Norway Read More »

Mucin modifies microbial composition and improves metabolic
functional potential of a synthetic gut microbial ecosystem

Gut Dysbiosis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Microbial dysbiosis in the gut is associated withhuman diseases, and variations in mucus alter gut microbiota.Therefore, we explored the effects of mucin on the gut microbiotausing a community of 19 synthetic gut microbial species. Cultivationof these species in modified Gifu anaerobic medium (GAM)supplemented with mucin before synthetic community assemblyfacilitated substantial growth of the Bacteroides, Akkermansia,and

Mucin modifies microbial composition and improves metabolic
functional potential of a synthetic gut microbial ecosystem Read More »

Parkinson’s Disease: A Prionopathy?

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis /

The principal pathogenic event in Parkinson’s disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson’s disease and other neurological disorders with a shared

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Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Stroke /

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and theirhost. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional andfunctional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses todisease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability

Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome Read More »