research

Minor hallucinations in isolated rapid eye movement sleep behavior disorder indicative of early phenoconversion: A preliminary study

iRBD /

Minor hallucinations (MH) are psychotic symptoms that can occur anywhere between prodromal to early Parkinson’s disease and after onset of motor problems. MH include visual illusions, presence hallucinations, and passage hallucinations. Isolated rapid eye movement sleep behavior disorder (RBD) is a harbinger of neurodegenerative diseases. We conducted a retrospective cohort study to investigate the clinical […]

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Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

Oral Microbiome, Parkinson's Disease, Periodontitis, Pre-PD, Root Canal /

Periodontitis is a low-grade inflammatory disease caused by a subgingivaldysbiotic microbiota. Multiple studies have determined the higher prevalence of toothloss and poor oral hygiene in patients with Alzheimer’s disease (AD). However, theperiodontal diagnosis, periodontal bacteria or mediators has not been measuredto date. Aim: To determine the periodontal status, the pro-inflammatory mediators,Porphyromonas gingivalis load, and Apoliporpotein

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Effect of vagotomy on modulation of dopaminergic neurons in Parkinson’s disease

A-Synuclein, Gut-Brain axis, Parkinson's Disease, Vagal Nerve /

Our results suggest that vagotomy has protective effects onnigrostriatal dopaminergic degeneration and disease progression insubsequent Parkinson’s disease, but may be unfavorable for cognitiveperformance. The neuroprotective effect of vagotomy could be largelymediated by blocking the spread of α-synuclein from the gut to the brain,and the modulation of inflammatory response might also contribute tosome extent. CLICK TO

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The Role of Dysbiosis in Neurological Disorders

Biomarkers, Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The gut brain axis is a system of bi-directional communication. When the delicate balance of the microbiome is disrupted, the resulting dysbiosis can be a factor in the development of neurological disorders, including Alzheimer’s Disease (AD), Parkinson’s Disease (PK), and Multiple Sclerosis (MS). One major player in the gut brain axis are short-chain fatty acids

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Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease

Gut-Brain axis, Lectins, Parkinson's Disease, Vagal Nerve /

Lectins from dietary plants have been shown to enhance drug absorption in the gastrointestinal tract of rats, be transported trans-synaptically as shown by tracing of axonal and dendritic paths, and enhance gene delivery. Other carbohydrate-binding protein toxins are known to traverse the gut intact in dogs. Post-feeding rhodamine- or TRITC-tagged dietary lectins, the lectins were

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease Read More »

Alerting Network Alteration in Isolated Rapid Eye Movement Sleep Behavior Disorder Patients with Mild Cognitive Impairment

iRBD /

Our findings indicate that when cognition is reduced to MCI levels in iRBD patients, the attention network, especially the alerting component, is impaired. The attention network and cognition, on the other hand, can be preserved in iRBD patients due to the compensatory mechanism. CLICK TO REVIEW Keywords REM sleep behavior disorder, Event-related potentials, Attention network

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Shining light on the head: Photobiomodulation for brain disorders

Parkinson's Disease, Photobiomodulation (PBM) /

Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by

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Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies

A-Synuclein, Biomarkers, Dementia - Lewy Bodies, Parkinson's Disease, Pre-PD /

The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in disease pathophysiology. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has recently shown high sensitivity and specificity for the detection of misfolded α-Syn in patients with Parkinson’s disease (PD) and

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Effect of Fiber and Fecal Microbiota Transplantation Donor on Recipient Mice Gut Microbiota

Fecal Transplants (FMT), Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

Both fecal microbiota transplantation (FMT) and dietary fiber intervention were verified as effective ways to manipulate the gut microbiota, whereas little is known about the influence of the combined methods on gut microbiota. Here, we constructed “non-industrialized” and “industrialized” gut microbiota models to investigate the donor effect of FMT and diet effect in shaping the

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$9M Grant Funds Study of Gut-Brain Connection in Parkinson’s Disease

A-Synuclein, Gut Dysbiosis, Gut-Brain axis, Symptoms / Diagnosis, Vagal Nerve /

Dr. Michael Kaplitt, a professor of neurological surgery at Weill Cornell Medicine and a longtime leader in developing cutting-edge surgical therapies for movement disorders, leads a team that has been awarded a three-year, $8.9 million grant from the Aligning Science Across Parkinson’s (ASAP) initiative. The grant will fund an ambitious and innovative multi-institutional collaborative effort to study

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