research

Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

A-Synuclein, Biomarkers /

The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing this gap we might improve our understanding of proteinopathic disorders that predominate in one sex. Therefore, we exposed male or female primary hippocampal cultures to preformed α-synuclein fibrils in a […]

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The Effect of a Probiotic Complex on the Gut-Brain Axis: A Translational Study

Biomarkers, Gut Microbiota, Metabolites, Probiotics, Prebiotics and Symbiotics /

A significant improvement of cognitive functions, in terms of short-termmemory, attention, and executive performance, as well as ofpsychophysiological markers, such as salivary cortisol level,skin conductance, sleep quality, and anxiety, were observed.Conclusions: According to the results, L. reuteri PBS072 andB. breve BB077 are potential probiotic candidates for improving stress resilience, cognitive functions, and sleep quality CLICK

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The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients

Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a complex brain disorder involving a multitude ofcontributing factors ranging from environmental to genetic. Interestingly, it has been foundthat the gut microbial community is altered in PD patients when compared to that of non-PDindividuals. However, the factors contributing to altered gut microbiota remain largelyunexplored. As such, the first objective of our

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The effect of oral butyrate administration on the release of serotonin and dopamine in the gastrointestinal trac

Butyrate, Gut Microbiota, Gut-Brain axis /

The microbiota-gut-brain axis is a modern concept with wide and physiologically important effects.The aim of the study was to investigate if an orally given short chain fatty acid (SCFA), butyrate,stimulates the formation and release of serotonin and dopamine in an in vivo rat model. The effect ofbutyrate was investigated in the entire gastrointestinal tract since

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Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms best, while deep brain stimulation (DBS) is effective for advanced PD patients; however, side effects occur with the diminishing therapeutic window. Recently, Lactiplantibacillus plantarum PS128 (PS128) was found to elevate dopamine levels in rodent brains, suggesting its

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Parkinson’s disease risk genes act in glia to control neuronal α-synuclein toxicity

A-Synuclein, Parkinson's Disease /

We identified 4 modifiers: aux, Lrrk, Ric, and Vps13, orthologs of the human genes GAK, LRRK2, RIT2, and VPS13C, respectively. Knockdown of each gene exacerbated neurodegeneration as measured by total and dopaminergic neuron loss. Knockdown of each modifier also increased α-synuclein oligomerization. These results suggest that some Parkinson’s disease risk genes exert their effects in glia and that glia can influence

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Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Vitamins / Supplements / Nutraceuticals /

Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas decreases were observed for Bacteroidetes (p < 0.01), Enterococci (p < 0.01) and Gemmiger formicilis (p < 0.05). In addition, trends for bacterial shifts were observed for Blautia (increase) and Streptococcus thermophilus (decrease). High-dose vitamin

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Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontists

Periodontitis /

In conclusion, the present study revealed that quercetin ameliorated the oxidative damage and improved the antioxidative ability of PDLCs by activating the NRF2 signaling pathway in vitro and in vivo (Figure 7). In addition, quercetin could prevent alveolar bone absorption in periodontitis. Therefore, quercetin may be a potential therapeutic candidate for treatment of periodontitis. CLICK

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Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease

Diet and Exercise, Parkinson's Disease, Pre-PD /

In a case–control study with 38 patients with PD and 33 controls, we assessed dietary intake using food frequency questionnaires and simultaneously measured the plasma levels of five PUFA. No differences were observed in dietary total energy and lipid intake, including PUFA, between patients with PD and controls. However, α-linolenic acid (ALA), linoleic acid (LA),

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Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial

Diet and Exercise, Parkinson's Disease /

A significant interaction effect between groups and time were observed F(1, 39) = 4.566, P = .036, where the sensory group improved in comparison to the boxing group. Post hoc analysis revealed that in comparison to boxing, the effects of exercise did not wear off at washout (week 20) P < .006. Conclusion. Future rehabilitation

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