research

Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease

A-Synuclein, Fecal Transplants (FMT), Gut Dysbiosis, Olfactory, Vagal Nerve, Zonulin /

Parkinson’s disease (PD) is characterized by alpha-synuclein misfolding with subsequent intraneuronal amyloid formation and accumulation, low grade neuroinflammatory changes, and selective neurodegeneration. Available evidence suggests that thepathology usually begins in the gut and olfactory mucosa, spreading to the brain via the vagus and olfactory nerves, by a prion-like mechanism. A causal relationship has not been […]

Serum and Fecal Markers of Intestinal Inflammation and Intestinal Barrier Permeability Are Elevated in Parkinson’s Disease Read More »

Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Biomarkers, Gut Dysbiosis, Gut Microbiota, Hydrogen, Metabolites, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are

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Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Herbs & Spices, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

The cross-reactivity and sequence homology between α-synuclein and frequently consumed foods, reinforces the autoimmune aspect of Parkinson’s disease. It is hypothesized that luminal food peptides that share cross-reactive epitopes with human α-synuclein and have molecular similarity with brain antigens are involved in the synucleinopathy. The findings deserve further confirmation by extensive research. CLICK TO REVIEW

Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson’s Disease Synucleinopathy Read More »

A randomised controlled trial on effectiveness and feasibility of sport climbing in Parkinson’s disease

Biomarkers, Diet and Exercise, Parkinson's Disease, Pre-PD /

Physical activity is of prime importance in non-pharmacological Parkinson’s disease (PD) treatment. The current study examines the effectiveness and feasibility of sport climbing in PD patients in a single-centre, randomised controlled, semi-blind trial. A total of 48 PD patients without experience in climbing (average age 64 ± 8 years, Hoehn & Yahr stage 2–3) were assigned either

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Objective vowel sound characteristics and their relationship with motor dysfunction in Asian Parkinson’s disease patients

Parkinson's Disease, Pre-PD /

Our study provides objective evidence of phonatory dysfunction in Asian PD patients with certain characteristics correlated with advanced stage or different motor dysfunction. Sustained vowel phonation is a promising digital outcome for global phenotyping a large number of PD patients. CLICK TO REVIEW

Objective vowel sound characteristics and their relationship with motor dysfunction in Asian Parkinson’s disease patients Read More »

Exploration of Host Health Benefits by a Defined Consortium of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Metabolites, Mitochondria, Short Chain Fatty Acids /

Aberrant gut microbiota composition is found to be associated with several human diseases such as inflammatory bowel diseases (IBD). Reduction in butyrate producing bacteria is one of the characteristic features of such dysbiotic bacterial community in the gut. Modulation of gut microbiota to bring the dysbiotic state back to normal healthy state is a promising

Exploration of Host Health Benefits by a Defined Consortium of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model Read More »

Identification and Characterization of Butyrate-Producing Species in the Human Gut Microbiome

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria, Short Chain Fatty Acids /

Inflammatory Bowel Diseases (IBD) including ulcerative colitis, Crohn’s disease, and indeterminate colitis are increasingly common conditions that places a high physical and financial burden on individuals and global healthcare systems. Though treatments exist for these conditions, their unpredictable nature and causation make them difficult to manage consistently across the variety of IBD patients. Additionally, many

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Increased Host Energy Metabolism in the Proximal Colon-Microbiota Interface Elevates Blood Pressure

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Collectively our data reported here is the first to provide evidence for a direct relationship between host energy metabolism at the proximal gut-microbiota interface and BP regulation. Further, our studies suggest that butyrate, which is a predominant colonic energy metabolite, contributes to the mechanism governing this relationship between energy metabolism in the proximal colon with

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Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

These data indicate that pathogen disruption of the epithelial mitochondrial network is a component of IBD that could identify novel targets to control enteric inflammation. These data underscore the complex bacterial-epithelium interaction: commensal organisms may preserve the mitochondrial network in the face of challenge from pathogens that seek to disrupt mitochondrial form and function. CLICK

Commensal Bacteria Derived Metabolite Butyrate Restores the Epithelial Mitochondrial Network Disrupted by the Crohn’s Disease-Associated Pathobiont Adherent Invasive E-coli Infection Read More »

Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study

Biomarkers, Parkinson's Disease, Pre-PD /

The gut microbiome appears to be predictive of Parkinson’s disease (PD) with constipation. Chronic constipation frequently manifests prior to motor symptoms and impairs quality of life. An osteopathic manipulative medicine (OMM) sequence used physical exam assessment and manual treatment of neuromusculoskeletal dysfunctions pertinent to constipation in PD for this prospective ABA-design study, IRB-NYITBHS1065. The effects

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