research

Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides

Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Inulin and GOS diets were associated with increased butyrate production and better anastomotic healing. Histological analysis revealed an enhanced mucosal continuity, and this was associated with an increased re-epithelialization of the wound as determined by increased epithelial proliferation. Collagen concentration in peri-anastomotic tissue was higher with inulin and GOS diets and MMP activity, a marker […]

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Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats

Butyrate, Gut Dysbiosis, Gut-Brain axis, Short Chain Fatty Acids /

Short chain fatty acids readily crosses the gut-blood and blood–brain barrier and acts centrally to influence neuronal signaling. We hypothesized that butyrate, a short-chain fatty acid produced by bacterial fermentation, in the central nervous system may play a role in the regulation of intestinal functions. Colonic permeability and visceral sensation was evaluated in rats. Septic

Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats Read More »

Systematic video-analysis of motor events during REM sleep in idiopathic REM sleep behavior disorder, follow-up and DAT-SPECT

Biomarkers, iRBD /

Patients with higher amounts of violent Motor Events had a greater risk of phenoconversion; therefore, their role as a predictor should be considered. Additionally, ME were associated with nigrostriatal degeneration, according to DAT-SPECT. These findings indicate that the degree of the clinical severity of motor manifestations in iRBD reflects the severity of the disease. CLICK

Systematic video-analysis of motor events during REM sleep in idiopathic REM sleep behavior disorder, follow-up and DAT-SPECT Read More »

Gut Microbiome Changes with Osteopathic Treatment of Constipation in Parkinson’s Disease: A Pilot Study

Biomarkers, Constipation, Gut Microbiota /

The gut microbiome shifted among individuals with constipation and PD after four weekly treatments with the OMM-sequence. Changes in the gut microbiome Post-OMM were associated with UPDRS results and constipation measures. Clinical trials and studies to develop the gut microbiome into a validated biomarker for PD are necessary to understand the impact of OMM in

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Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Parkinson’s disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes. However, its pathological mechanism remains undetermined. Accumulating evidence has revealed the emerging functions of gut microbiota and microbial metabolites, which can affect both the enteric nervous system and the central nervous system via the microbiota-gut-brain axis. Accordingly, intestinal dysbiosis might be closely associated

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Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson’s disease

Butyrate, Short Chain Fatty Acids /

Finally, the pros and cons of the current treatments for PD, including those targeting microbiota, are assessed. Advancements in research techniques, further studies on levels of specific strains and longitudinal prospective clinical trials are urgently needed for the identification of early diagnostic markers and the development of novel therapeutic approaches for PD. CLICK TO REVIEW

Neuroprotective effects of short-chain fatty acids in MPTP induced mice model of Parkinson’s disease Read More »

Air pollution, surrounding green, road proximity and Parkinson’s disease: A prospective cohort study

Parkinson's Disease /

We found that PM2.5 were associated with increased risk of incident PD while surrounding green was associated with decreased risk of PD. Future studies about PD etiology may benefit from including multiple environmental exposures to address potential joint associations. CLICK TO REVIEW

Air pollution, surrounding green, road proximity and Parkinson’s disease: A prospective cohort study Read More »

Voice for Health: The Use of Vocal Biomarkers from Research to Clinical Practice

Speech /

Diseases can affect organs such as the heart, lungs, brain, muscles, or vocal folds, which can then alter an individual’s voice. Therefore, voice analysis using artificial intelligence opens new opportunities for healthcare. From using vocal biomarkers for diagnosis, risk prediction, and remote monitoring of various clinical outcomes and symptoms, we offer in this review an

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Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice

Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be discovered, the functional details of how the microbiota-gut-brain-axis works are starting to be resolved. Previous studies have suggested B. longum can cause changes in brain chemistry and activity [20]. Other research has revealed that modifications to expression of

Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice Read More »