Studies of the gut microbiota on health and disease are of high importance, and the role of probiotics and prebiotics as modulators of the microbiota require studies to find the best candidates. The obtained results show that the Lactobacillus strains evaluated possess properties such as adherence to cultured cells, inhibition of the colonization and growth […]
Automated speech analysis may provide a useful additional biomarker of parkinsonism for the assessment of disease progression and therapeutic interventions. CLICK TO REVIEW
Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population CLICK TO REVIEW
We provide evidence that the α-synuclein RT-QuIC assay enables the molecular detection of neuronal α-synuclein aggregates in olfactory mucosa of patients with isolated RBD and Parkinson’s disease. Although the overall sensitivity was moderate in this study, nasal swabbing is attractive as a simple, non-invasive test and might be useful as part of a screening battery
Dermal p-syn in iRBD is most probably an early consistent marker of synucleinopathy and may support other indicators of conversion to manifest disease state. CLICK TO REVIEW
Despite increased microglial recruitment to Ab plaques upon SCFA supplementation, microglia contained less intracellular Ab. Taken together, our results demonstrate that microbiota-derived SCFA are critical mediators along the gut-brain axis which promote Ab deposition likely via modulation of the microglial phenotype. CLICK TO REVIEW
Linear trends across the pre-ordered OH subtypes found that clinical parameters worsened along with the orthostatic challenge. Clinical scales deteriorated and the linear gradient was maintained during the follow-up period. This study suggests that delayed OH is a mild form of classical OH in PD. PD with delayed OH has milder disease severity and progression.
Delayed orthostatic hypotension in Parkinson’s disease Read More »
In this cross-sectional study of a male population, probable sleep parasomnias, including both SW and RBD, were associated with higher odds of having PD. PD-related neurodegeneration may impair arousal regulation during sleep CLICK TO REVIEW
At 12 weeks post-injection, a separate 43 and distinct pattern of structural and sensory-evoked functional brain activity changes was 44 observed that are co-localized with previously reported regions of α-syn pathology and immune 45 activation. Microstructural changes in the pons at 12 weeks post-injection were found to predict 46 survival time and preceded measurable locomotor
This study showed that consumption of a multi-strain probiotic (Hexbio®) over 8 weeks improved bowel opening frequency and whole gut transit time in PD patients with constipation. CLICK TO REVIEW