research

REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder

iRBD /

Brainstem neurophysiology as evidenced by altered VEMPs in patients with PD and iRBD could reflect disease evolvement. Moreover, VEMPs alterations may vary depending on the presence of RBD in PD patients. The associations between altered RSWA and VEMP parameters highlight the meaningfulness of detecting brainstem dysfunction in early-stage PD. Keywords Parkinson’s disease vestibular-evoked myogenic potentials […]

REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder Read More »

Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients

iRBD, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may reflect its pathogenesis. Methods: We compared motor function and non-motor symptoms (NMSs) between iRBD patients and healthy volunteers. We correlated motor function, NMSs, and striatal dopaminergic activity with RBD severity using video-polysomnography. Results: Twenty-one iRBD

Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients Read More »

An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population

Ayahuasca, Breath /

Background Holotropic breathwork (Grof ® Breathwork), was developed by Stanislav Grof and Christina Grof as a ‘non-drug’ alternative technique to evoke altered states of consciousness (ASC). Interestingly, although HBW has been anecdotally reported to evoke experiences and mental health effects corresponding to those of psychedelic substances, the scientific literature on the matter is scarce. Aims

An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population Read More »

S889 Effects of Etoh on Human Intestinal Epithelial and Microvascular Endothelial Cells (HIMEC) in Patients With Inflammatory Bowel Disease: An in-vitro Exploration

Butyrate, Gut Dysbiosis /

Ethanol (EtOH) is associated with IBD flares, but the exact mechanisms are not well-known. Gut dysbiosis and depleted luminal butyrate are both linked with IBD and EtOH exposure. We tested our hypothesis that EtOH-induced gut dysbiosis and depleted butyrate levels disrupt intestinal epithelial junctional proteins which facilitates ethanol and endotoxin interaction with intestinal microvascular endothelial

S889 Effects of Etoh on Human Intestinal Epithelial and Microvascular Endothelial Cells (HIMEC) in Patients With Inflammatory Bowel Disease: An in-vitro Exploration Read More »

Neuroprotection of chicoric acid in a mouse model of Parkinson’s disease involves gut microbiota and TLR4 signaling pathway

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Chicoric acid (CA), a polyphenolic acid obtained from chicory and purple coneflower (Echinacea purpurea), has been regarded as nutraceutical to combat inflammation, virus and obesity. Parkinson’s Disease (PD) is a common neurodegenerative disorder, and microbiota-gut-brain axis might be the potential mechanism in the pathogenesis and development of PD. The results here demonstrated that oral pretreatments

Neuroprotection of chicoric acid in a mouse model of Parkinson’s disease involves gut microbiota and TLR4 signaling pathway Read More »

Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells

Autophagy, Butyrate, Parkinson's Disease, Short Chain Fatty Acids /

Short-chain fatty acids (SCFAs) are considered the key molecular link between gut microbiota and pathogenesis of Parkinson’s disease (PD). However, the role of SCFAs in PD pathogenesis is controversial. Autophagy is important for the degradation of α-synuclein, which is critical to the development of PD. However, whether SCFAs can regulate autophagy in PD remains unknown.

Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells Read More »

Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease

Autophagy, Parkinson's Disease /

One of the potential benefits of using data-independent acquisition (DIA) proteomics protocols is that information not originally targeted by the study may be present and discovered by subsequent analysis. Herein, we reanalyzed DIA data originally recorded for global proteomic analysis to look for isomerized peptides, which occur as a result of spontaneous chemical modifications to

Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease Read More »

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models

Parkinson's Disease, Pre-PD, Vitamins / Supplements / Nutraceuticals /

Parkinson’s disease (PD) is a neurodegenerative disordercharacterized by a progressive loss of dopaminergic neu-rons in the substantia nigra (SN). The present study wasdesigned to examine the therapeutic effect of hydrogensulfide (H2S, a novel biological gas) on PD. The endoge-nous H2S level was markedly reduced in the SN in a6-hydroxydopamine (6-OHDA)-induced PD rat model. Sys-temic administration

Neuroprotective effects of hydrogen sulfide on Parkinson’s disease rat models Read More »

Association Between Parkinson’s Disease and Atrial Fibrillation: A Population-Based Study

A-Synuclein, Autonmic nervous system, Parkinson's Disease, Pre-PD /

Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson’s disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. This study demonstrated that the premotor and early stages of PD were comorbid with AF, whereas

Association Between Parkinson’s Disease and Atrial Fibrillation: A Population-Based Study Read More »

Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways

Parkinson's Disease, Pre-PD /

Taurine (Tau) is one of the most abundant amino acids in the brain and regulates physiological functions in the central nervous system, including anti-inflammatory effects. There is growing evidence that microglia-mediated neuro-inflammatory responses are an integral part of Parkinson’s disease (PD) onset and progression. Among the many factors regulating the inflammatory response, phosphatidylinositol-3 kinase (PI3K)

Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways Read More »