Although oxidative agents such as free radicals can fight pathogens, an imbalance of oxidants to anti-oxidant activity can lead to harmful effects in our body known as oxidative stress. Various cellular organelles produce oxidative agents as well as anti-oxidants. The main oxidative stressors are classified under the free radical species; reactive oxygen species and reactive […]
Alzheimer’s disease (AD) is a global public health priority as with aging populations, its prevalence is expected to rise even further in the future. The brain and gut are in close communication through immunological, nervous and hormonal routes, and therefore, probiotics are examined as an option to influence AD hallmarks, such as plaques, tangles, and
The pathophysiology of schizophrenia spectrum disorders and associated mood disordersis complex and highly heterogeneous, suggesting that different molecular pathways are involvedin it. Among those, the microbiome and its connection to the brain (“gut-brain axis”) has emergedas a highly promising research avenue. To evaluate the role of the human microbiome in the gutbrain axis, we evaluated
The gut microbiota is highly capable of biotransformation, exposing the host to a wide varietyof physiologically active compounds. These metabolites participate in signaling between thegastrointestinal tract and the central nervous system and may regulate physiological andpathological processes in the central nervous system. This bidirectional communication cantake place in a variety of ways, including binding to
Metabolites from the Gut Microbiota and the Role in the
Gut-Brain Axis Read More »
Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases
Research progress on the association of neurological disorders and periodontal diseases Read More »
Parkinson’s disease (PD) is a neurological disorder associated with severe loss of dopaminergic neurons inthe substantia nigra. These neurons are particularly vulnerable due to increased iron and decreasedantioxidant levels with aging, constant exposure to reactive oxygen species (ROS), and the presence ofneurotoxic compounds. A literature review was compiled and published, in which we postulate that
Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N’N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown bymonoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a β-carbolinein the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was provoked in eyes of rats,followed by 7 days of reperfusion
Therapeutic Properties of Ayahuasca Components in
Ischemia/Reperfusion Injury of the Eye Read More »
Dietary restriction of carbohydrates has been demonstrated to be beneficial for nervous system dysfunction in animal models and may be beneficial for human chronic pain. The purpose of this review is to assess the impact of a low-carbohydrate/ketogenic diet on the adult nervous system function and inflammatory biomarkers to inform nutritional research for chronic pain.
Parkinson’s disease (PD) is a complex neurodegenerative condition with a multifactorial origin. To date, approaches todrug discovery for PD have resulted in symptomatic therapies for the motor manifestations and signs associated withneurodegeneration but have failed to identify preventive or curative therapies. This failure mainly originates from thepersistence of major gaps in our understanding of the
The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on thelocalized regions, microbiota can be classified into gut, oral, respiratory, and skin microbiota. The microbial communities are insymbiosis with the host, contributing to homeostasis and regulating immune function. However, microbiota dysbiosis can lead todysregulation of bodily
Microbiota in health and diseases Read More »