review

Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Ayahuasca, Parkinson's Disease, Pre-PD /

Psychedelics are increasingly being recognized for their potential to treat a wide range of braindisorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder.Their broad therapeutic potential might result from an ability to rescue cortical atrophy common tomany neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor geneexpression, activating neuronal growth and survival mechanisms, and […]

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The gut connection: Intestinal permeability as a pathway from breast cancer survivors’ relationship satisfaction to inflammation across treatment

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

The gut environment is a new promising candidate for understanding a relationship’s long-term health impact, particularly among those with elevated health risks. Survivors may reap multiple physiological benefits from satisfying relationships. CLICK TO REVIEW Keywords Cancer survivors, Gut microbiota, Inflammation Intestinal permeability Marriage Romantic relationships

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The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

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An Update on the Critical Role of α-Synuclein in Parkinson’s Disease and Other Synucleinopathies: from Tissue to Cellular and Molecular Levels

A-Synuclein, Parkinson's Disease /

The aggregation of alpha-synuclein (α-Syn) plays a critical role in the development of Parkinson’s disease (PD) and other synucleinopathies. α-Syn, which is encoded by the SNCA gene, is a lysine-rich soluble amphipathic protein normally expressed in neurons. Located in the cytosolic domain, this protein has the ability to remodel itself in plasma membranes, where it

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Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

Biomarkers, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF)

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Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study

Diet and Exercise, Parkinson's Disease, Pre-PD /

The Mediterranean diet has been associated with the risk of Parkinson’s disease (PD),but limited research has been performed on other dietary patterns. We studied the relationshipbetween overall diet quality and PD risk in the general population. We included 9414 participantsfrom the Rotterdam Study, a prospective population-based study in the Netherlands. Diet wasdefined using a Dutch

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Gut Microbiota Regulation and Their Implication in the Development of Neurodegenerative Disease

Fecal Transplants (FMT), Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Vagal Nerve /

In recent years, human gut microbiota have become one of the most promising areasof microorganism research; meanwhile, the inter-relation between the gut microbiota and varioushuman diseases is a primary focus. As is demonstrated by the accumulating evidence, the gastrointestinal tract and central nervous system interact through the gut–brain axis, which includesneuronal, immune-mediated and metabolite-mediated pathways.

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Melatonin as first-line treatment for sleep disorders in Parkinson’s disease?

Biomarkers, iRBD, Pre-PD /

Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear.

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