review

Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review

Periodontitis, Root Canal /

All the included studies reported higher levels of inflammatory markers, IgG levels of periodontal bacteria, and/or clinical parameters of periodontitis with the two concomitant diseases (some neurodegenerative disease and periodontitis), compared with the diseases isolated (summarized in Figure 2). Despite that we found some minor problems in domains in the qualitative analysis, all the studies have […]

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Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer’s Disease

Fecal Transplants (FMT), Parkinson's Disease /

Microbiota-targeted interventions such as personalized diet, probiotics, or fecal microbiota transplantation (FMT) might represent a potential therapeutic option for AD. This review article discusses the procedure of FMT and its possible side effects on the recipient’s body. In addition, we review the role of FMT in the context of its application in various nervous system-related

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IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and

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Probiotics and the Treatment of Parkinson’s Disease: An Update

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and anti-inflammatory pathways, as well as apoptosis. Herein, we summarize the effects of probiotics on motor and non-motor symptoms as well as various cellular and molecular pathways in PD. CLICK TO REVIEW

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Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, weexamine the

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Food for thought: the emerging role of a ketogenic diet in Alzheimer’s disease management

Diet and Exercise /

Recently, particular attention has been paid to the possible function of three dietary patterns in AD prevention: the Mediterranean diet, the Dietary Approaches to Stop Hypertension (DASH) diet, and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. These dietary patterns have well-known anti-inflammatory and antioxidant properties, and their neuroprotective properties have been shown to be

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Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases

Gut Dysbiosis, Gut Microbiota, Mitochondria, Parkinson's Disease, Pre-PD /

One fundamental component of systemic homeostasis is the gut microbiota, which communicates withthe CNS via microbial metabolite production, the peripheral nervous system, and regulation oftryptophan metabolism. Over the past 10–15 years, research focused on the microbiota–gut–brainaxis has culminated in the discovery that dysbiosis, or an imbalance between commensal andpathogenic gut bacteria, can promote CNS pathologies.

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The role of oxidative stress and the underlying biological pathways in the pathogenesis of Parkinson’s Disease

Anti-oxidants, Mitochondria /

The mechanisms involved in pathogenesis and progression ofPD is not fully understood but there is overwhelming evidence thatmaintenance of redox potential is important for neuronal survival.Any disruption in the mitochondrial potential disrupts the cellularhomeostasis, which in turn causes more ROS production leadingto neuroinflammation and degeneration. The review attempts toconsolidate key signaling pathways, and proteins that

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Dietary patterns affect Parkinson’s disease via the microbiota-gut-brain axis

Diet and Exercise, Gut Microbiota, Short Chain Fatty Acids /

The Mediterranean diet reduces the risk of PD with favorable alternations of intestinal microbiota, increases levels of SCFAs, and reduces the TMAO level. Calorie restriction and Fasting-mimicking diet show some neuroprotective effects on PD via increasing β-HB, FGF21, and Ghrelin levels. Meanwhile, both ketogenic and protein-restricted diets show a striking effect on ameliorating motor impairment

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Early constipation predicts faster dementia onset
in Parkinson’s disease

Constipation, Dementia - Lewy Bodies /

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may bepart of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration,composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessedwith the MDS-UPDRS

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