review

Non-motor symptoms and their use as markers for prodromal and early Parkinson’s Disease

Non-Motor Symptoms, Pre-PD /

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is a disease with a broad spectrum of symptoms, both motor and non-motor, but is often only diagnosed when the motor symptoms begin to appear. By this time however, a large amount of the dopaminergic neurons of the substantia nigra pars compacta have already […]

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Impact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity

Diet and Exercise, Herbs & Spices, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

: The average life expectancy of the world population has increased remarkably in the past150 years and it is still increasing. A long life is a dream of humans since the beginning of time but also a dream is to live it in good physical and mental condition. Nutrition research has focused on recent decades

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Fasting: How to Guide

Diet and Exercise, Fasting /

Fasting potentials are the most interesting topics in the Nutritional Era. Fasting consists of the catabolism of lipids, proteins, and carbohydrates to maintain blood glucose levels in a normal range. The action mechanisms of fasting were firstly understood in minor organisms and later in humans. Nutritional interventions of caloric restriction could attenuate age-associated epigenetic alterations

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Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Butyrate, Gut Dysbiosis, Gut-Brain axis, Metabolites, Mitochondria, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Psychobiotics—live microorganisms with potential mental health benefits, which can modulate the microbiota-gut-brain-axis via immune, humoral, neural, and metabolic pathways—are emerging as novel therapeutic options for the effective treatment of psychiatric disorders Recently, microbiome studies have identified numerous putative psychobiotic strains, of which short-chain fatty acids (SCFAs) producing bacteria have attracted special attention from neurobiologists. Recent

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Therapeutic Properties of Edible Mushrooms and Herbal Teas in Gut Microbiota Modulation

Diet and Exercise, Gut Microbiota, Herbs & Spices /

Edible mushrooms are functional foods and valuable but less exploited sources of biologically active compounds. Herbal teas are a range of products widely used due to the therapeutic properties that have been demonstrated by traditional medicine and a supplement in conventional therapies. Their interaction with the human microbiota is an aspect that must be researched,

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Butyrate administration strengthens the intestinal epithelium and improves intestinal dysbiosis in a cholestasis fibrosis model

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Mitochondria /

Intestinal dysfunction in cirrhosis patients is linked to death by bacterial infections. Currently, there is no effective therapy for this complication. This study aims to evaluate butyrate, a novel postbiotic, on the intestinal inflammatory response, tight junction proteins, and the microbiota in the cholestasis model. Butyrate is effective in regulating the inflammatory response, tight junction

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Disease Modifying Potential of Functional Foods for Neurodegenerative Disorders: Status Update on Regulatory Compliance

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

Progressive loss of functional neurons is typically characterized as neurodegeneration. This is particularly pronounced during aging and results in debilitating conditions such as Parkinson’s disease and Alzheimer’s disease. Symptoms appear typically after 70–80% neuronal loss, resulting in irreversible damage. Several drugs have been clinically approved but they only alleviate symptoms and additionally lead to undesirable

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Ketogenic Diet and Health

Diet and Exercise, Fasting /

In recent years, emerging evidence suggests KD’s may also have therapeutic benefits for some cancers and for neurological conditions such asAlzheimer’s disease, Parkinson’s’ disease, multiple sclerosis, traumatic brain injury, and spinal cord injury. Finally, as the physiological mechanisms by which a KD operates become increasingly understood, we speculate that several other health conditions (e.g., autism,

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The gut microbiome: implications for neurogenesis and neurological diseases

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Short Chain Fatty Acids /

The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of

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Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease

Biomarkers, Parkinson's Disease /

This narrative review aimed to elaborate on the potential epigenomic treatments for PD and AD. About 199 scientific articles written in English, which reported on novel epigenomic-based treatment for PD and AD, were selected for this review from the PubMed database. Full articles and relevant data were extracted. Treatments targeting DNA methylation or miRNAs appear

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