review

The Potential Role of Cinnamon in Human Health

Parkinson's Disease, Pre-PD /

In folk medicine, cinnamon species have been used as medicine for respiratory and digestive disorders. Their potential for prophylactic and therapeutic use in Parkinson’s and Alzheimer’s disease has also been discovered. This review summarizes the available isolation methods and analytical techniques used to identify biologically active compounds present in cinnamon bark and leaves and the […]

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Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy

A-Synuclein, Dementia - Lewy Bodies, Diet and Exercise, iRBD, Pre-PD /

The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with

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Neurological disorders associated with impaired gut microbiota

Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It is becoming more widely recognized as a symptom of Autism Spectrum Disorder. The establishment of gut-brain psychology is expected to have a significant impact on psychology and related disciplines. CLICK TO REVIEW

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Supplementation of regular diet with medium-chain triglycerides for neuroprotective effects

Diet and Exercise, Short Chain Fatty Acids /

This review summarizes currently available research on the effects and revealed mechanisms of using MCTs as a supplement to standard feed/diet without concomitant reduction of carbohydrate intake, highlighting open questions and potential considerations.

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Butyrate, Gut Microbiota, Short Chain Fatty Acids /

It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurological disorders, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, and neuromyelitis optica spectrum disorders, among others. This review will discuss the current evidence from the most significant studies dealing with some SCFAs from gut microbial metabolism with selected neurological disorders. CLICK

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The microbiota-gut-brain axis and Alzheimer disease. From dysbiosis to neurodegeneration: focus on the central nervous system glial cells

Gut Dysbiosis, Gut-Brain axis /

Much evidence has accumulated over the past decade in favor of a significant association between dysbiosis, neuroinflammation and neurodegeneration. Presently, the pathogenetic mechanisms triggered by molecules produced by the altered microbiota, also responsible for the onset and evolution of Alzheimer Disease will be described. Our attention will be focused on the role of astrocytes and

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Does modern research validate the ancient wisdom of gut flora and brain connection?

Gut-Brain axis /

Both animal and human studies evaluating the role of gut dysbiosis on various neurological and neurosurgical diseases, published in peer-reviewed journals, were reviewed. Current studies do not provide conclusive evidence of a direct origin of CNS disorders from gut dysbiosis, but a possible modulatory role of gut microbiota in certain neurological disorders has been implicated.

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Diet-Microbiota-Brain Axis in Alzheimer’s Disease

Gut Microbiota /

A strong association exists between lifestyle factors and AD prevalence wherein unhealthy dietary factors have been linked to neurodegeneration. Specific prudent dietary patterns might help in preventing or delaying AD progression by affecting β-amyloid production and tau processing and regulating AD-associated inflammation, metabolism and oxidative stress, plausibly via modulating gut microbiota. CLICK TO REVIEW

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Parkinson’s is announced long before the diagnosis

Constipation, iRBD, Olfactory, Sleep /

Parkinson’s disease is a progressive disease of the brain caused by the death of special nerve cells. The disease is characterized by movement disorders such as slowing movements, stiffness of the muscles, tremors or specific changes in the gait pattern. Often there can be many years before these typical symptoms permit a diagnosis of Parkinson’s disease. These can

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Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment

Gut Dysbiosis, Gut Microbiota, Metabolites, Mitochondria /

The search for therapeutic targets for Parkinson’s disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous system are incompletely understood. Multiple lines of evidence suggest that the gut microbiota participates

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