review

The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

The role of Akkermansia muciniphila, one of the most abundant microorganisms of the intestinalmicrobiota, has been studied extensively in metabolic diseases, such as obesity and diabetes. Itis considered a next-generation probiotic microorganism. Although its mechanism of action hasnot been fully elucidated, accumulating evidence indicates the important role of A. muciniphilain brain functions via the gut-brain […]

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Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Parkinson Disease Patients

A-Synuclein, Butyrate, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

We are grateful for the comment on our study.1 We are pleased to know that short chain fatty acids (SCFA), especially butyrate, in the intestine could stimulate the colonization of curli-producing Escherichia coli (E. coli). Curli are functional amyloids produced by gut microbes and act as cross-beta-sheet amyloid polymers to assist bacterial cells in binding to

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Sleep Disorders and Autonomic Nervous System Dysfunction

iRBD, Pre-PD /

Parasympathetic nervous system activity dominates during non-rapid eye movement (REM) sleep, whereas the sympathetic nervous system is dominant during REM sleep. The balance between the sympathetic and parasympathetic nervous systems reduces the heart rate and blood pressure during non-REM sleep and increases these parameters during REM sleep and wakefulness. Heart rate variability analysis, a non-invasive

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Exploiting Caenorhabditis elegans to discover human gut microbiota-mediated intervention strategies in protein conformational diseases

A-Synuclein, Biomarkers, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Age-dependent protein-conformational diseases (PCDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the proteome of the affected individual. Recent evidence supports the notion that bacteria and bacterial products may be affecting the stability of these culprit host proteins and

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Predictors of RBD progression and conversion to synucleinopathies

Biomarkers, iRBD /

There is a variety of potential biomarkers for monitoring disease progression and predicting iRBD conversion into synucleinopathies. A combined multimodal biomarker model could offer a more sensitive and specific tool. Further longitudinal studies are warranted to iRBD as a high-risk population for early neuroprotective interventions and disease-modifying therapies. CLICK TO REVIEW

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Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options

Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing [1,2,3]. The increased morbidity of human populations makes them more vulnerable to additional burdens, including infectious diseases. For example, the mortality rate of diabetics infected with the original variant of the SARS Co-2 virus was about twice that of the general

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Inflammation and immune dysfunction in Parkinson disease

Gut Microbiota, Parkinson's Disease, Pre-PD /

Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral organs as well as the central nervous system and involves a fundamental role of neuroinflammation in its pathophysiology. Neurohistological and neuroimaging studies support the presence of ongoing and end-stage neuroinflammatory processes in PD. Moreover, numerous studies of peripheral blood and cerebrospinal fluid from patients

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Microbiota and the gut-brain-axis: Implications for new therapeutic design in the CNS

Gut Microbiota, Gut-Brain axis /

The recent revelation that the gut microbiome, home to approximately 100 trillion microorganisms, is implicated in the development of both health and disease has spurred an exponential increase in interdisciplinary research involving gut microbiology. In all this hype, there is a need to better understand and contextualize the emerging evidence for the role of the gut microbiota in

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Behavioral validation of the University of Michigan REM behavior disorder questionnaire in the synucleinopathies

iRBD /

Many questionnaires have been proposed to collect data related to dream enactment. These are typically validated by reference to objective measurements of polysomnography, which incorporate physiologic recording of muscle activity during sleep. Another approach to such questionnaire validation would be the direct behavioral observations of patients’ sleep. In the course of an ongoing study, we examined

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Intertwined Relationship of Mitochondrial Metabolism, Gut
Microbiome and Exercise Potential

Gut Microbiota, Mitochondria /

: The microbiome has emerged as a key player contributing significantly to the humanphysiology over the past decades. The potential microbial niche is largely unexplored in the contextof exercise enhancing capacity and the related mitochondrial functions. Physical exercise can influence the gut microbiota composition and diversity, whereas a sedentary lifestyle in association withdysbiosis can lead

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