review

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

Butyrate, Gut Dysbiosis, Gut Microbiota, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of psychiatry. This is largely due to the many overlapping pathophysiological mechanisms associated with both the potential functionality of the gut microbiota and the biological mechanisms thought to be underpinning mental disorders. In this […]

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The Complement System in the Central Nervous System:
From Neurodevelopment to Neurodegeneration

Uncategorized /

The functions of the complement system to both innate and adaptive immunity throughopsonization, cell lysis, and inflammatory activities are well known. In contrast, the role of complement in the central nervous system (CNS) which extends beyond immunity, is only beginning to berecognized as important to neurodevelopment and neurodegeneration. In addition to protecting thebrain against invasive

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From Neurodevelopment to Neurodegeneration Read More »

Adult Neurogenesis under Control of the Circadian System

Photobiomodulation (PBM) /

The mammalian circadian system is a hierarchically organized system, which controls a24-h periodicity in a wide variety of body and brain functions and physiological processes. Thereis increasing evidence that the circadian system modulates the complex multistep process of adultneurogenesis, which is crucial for brain plasticity. This modulatory effect may be exercised viarhythmic systemic factors including

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Role of Microbiota-Gut-Brain Axis in Regulating
Dopaminergic Signaling

Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Dopamine is a neurotransmitter that plays a critical role both peripherally and centrally invital functions such as cognition, reward, satiety, voluntary motor movements, pleasure, and motivation. Optimal dopamine bioavailability is essential for normal brain functioning and protectionagainst the development of neurological diseases. Emerging evidence shows that gut microbiotahave significant roles in maintaining adequate concentrations of

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Dopaminergic Signaling Read More »

The promise of psychedelic research

Ayahuasca, Parkinson's Disease, Pre-PD /

The use of psychedelics as medicines and for overall better brain health is potentially one of the mosttransformative developments given their immediate and long-lasting therapeutic effects across a plethoraof neuropsychiatric disorders and, more recently, some neurodegenerative diseases. The US psychedelicdrugs market is forecasted to grow by 16.3% by 2027 due to the increasing prevalence of

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α-Synuclein in Parkinson’s disease and advances in detection

A-Synuclein, Biomarkers, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a threatening neurodegenerative disorder that seriously affects patients’ life quality. Substantial evidence links the overexpression and abnormal aggregation of alpha-synuclein (α-Syn) to PD. α-Syn has been identified as a characteristic biomarker of PD, which indicates its great value of diagnosis and designing effective therapeutic strategy. This article systematically summarizes the pathogenic

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Parkinson’s disease: Are gut microbes involved?

Biomarkers, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

Parkinson’s disease (PD) isa common neurodegenerative disorder characterized by motor and gastrointestinal(GI) deficits. Despite its prevalence, the pathophysiology of PD is not wellunderstood. Recent studies highlight the role of gut microbiota in neurologicaldisorders. In this review, we summarize the potential role of gut microbiota inthe pathophysiology of PD. We first describe how gut microbiota can

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Effects of Endurance Training on Motor Signs of Parkinson’s Disease: A Systematic Review and Meta-Analysis

Parkinson's Disease /

Evidence has demonstrated that endurance training (ET) reduces the motor signs of Parkinson’s disease (PD). However, there has not been a comprehensive meta-analysis of studies to date. ET is effective in decreasing UPDRS-III scores. Questions remain about the dose–response relationship between ET and reduction in motor signs. CLICK TO REVIEW

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Neuroinflammation as a Common Mechanism Associated with the Modifiable Risk Factors for Alzheimer’s and Parkinson’s Diseases

Parkinson's Disease /

Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent

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Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each

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Axis with Neurotoxicity Read More »