review

Gut–Brain Axis: Role of Gut Microbiota in Neurodegenerative Disease

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The role of gut bacteria in neurodegenerative disease has long been speculated; however, the extent of influence and the exact composition of microflora that mechanistically alter outcomes are less understood. While aging was thought to be a major contributor to neurodegenerative disease, the role of the immune system started to become more appreciated bringing the […]

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Gastrointestinal Dysfunction in Parkinson’s Disease

Gut Dysbiosis, Vagal Nerve /

There has been exponential growth in the awareness and understanding of gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) over the past 3 decades. The clinical features of GI dysfunction in PD have been clearly identified and innovative research has demonstrated the presence of pathology within the enteric nervous system (ENS) in individuals with PD, leading

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Gut Microbiota and Short Chain Fatty Acids: Implications in
Glucose Homeostasis

Biomarkers, Butyrate, Gut Microbiota, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

: Gut microbiota encompasses a wide variety of commensal microorganisms consisting oftrillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host,and related metabolites have profound effects on human health. In this respect, gut microbiota playsa pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolitesinclude the short

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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

Butyrate, Gut-Brain axis, Short Chain Fatty Acids /

The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in

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Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied

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Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

Parkinson’s disease is characterized by motor and non-motor symptoms, such as defects in the gut function, which may occur before the motor symptoms. To date, there are therapies that can improve these symptoms, but there is no cure to avoid the development or exacerbation of this disorder. Dysbiosis of gut microbiota could have a crucial

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The second brain in Parkinson’s disease: fact or fantasy?

Fecal Transplants (FMT), Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

We have briefly expressed three components that are significant in promoting the complex involvement of the gut within PD. Thorough research has looked into the physiology and symptoms of PD, with further exploration into the gut microbiota a crucial step in truly understanding the disease process. Adopting strategies to ensure stable, healthy microbial consumption along

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Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation

Enviromental, Parkinson's Disease, Root Canal, Viral / Bacterial Infections, Virus /

Exposure to systemic infections causes neurodegeneration in brain regions displaying amyloid pathology and high local microglia density. AD brains exhibit increased susceptibility to microbial PAMPs’ neurotoxicity, which accelerates neuronal death. Microglial modulation protects the brain from microbial TLR agonist PAMP-induced neurodegeneration. CLICK TO REVIEW

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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease /

The human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome. The initial acquisition of microbiota occurs from both the external and maternal environments, and the vast majority of them colonize the gastrointestinal tract (GIT). These microbial communities play a central role in

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Dairy Intake and Parkinson’s Disease: A Mendelian Randomization Study

Diet and Exercise, Parkinson's Disease /

Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society CLICK TO REVIEW

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