Background: Over the last three decades, consumption of total and saturated fat has steadily declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 fatty acid intake has risen at the expense of ω-3 fatty acids, resulting in an ω-6/ω-3 ratio of 20:1 or higher. Scope and approach: The […]
It has been proven that physical exercise improves cognitive function and memory, hasan analgesic and antidepressant effect, and delays the aging of the brain and the development ofdiseases, including neurodegenerative disorders. There are even attempts to use physical activity inthe treatment of mental diseases. The course of most diseases is strictly associated with oxidativestress, which
Physical Activity vs. Redox Balance in the Brain: Brain Health, Aging and Diseases Read More »
Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and nonmotor complications. Autonomic alterations, including gastrointestinal symptoms, precede motordefects and act as early warning signs. Chronic exposure to dietary, environmental heavy metalsimpacts the gastrointestinal system and host-associated microbiome, eventually affecting the centralnervous system. The correlation between dysbiosis and PD suggests a functional and bidirectionalcommunication
The gut microbiota (GM) is formed by millions of microorganisms present in the gastrointestinal tract, especially in the colon. This intestinal homeostasis can be triggered by the union of a good diet, and even recent studies have suggested that aerobic physical training can modify its composition. Objective:To analyze the influence of healthy eating added to
Gut microbiota related to nutrition and physical activity: an integrative review Read More »
Background: The aim of the study was to evaluate the effect of Tai Chi on functional mobility, balance and falls in Parkinson’s disease. Materials and methods: A comprehensive literature search was conducted to identify the systematic reviews and meta-analyses up to the end of October 2021. 601 studies were identified, and 16 of them were included in
This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain
Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD
Background A number of promising biomarkers for predicting imminent α-synucleinopathies have been suggested in isolated rapid eye movement sleep behaviour disorder (iRBD). However, existing evidence is conflicting without quantitative evaluation. Methods PubMed, Web of Science and ClinicalTrials.gov were searched through June 2021 to identify possible predictors of phenoconversion from iRBD to Parkinson’s disease (PD). The pooled HRs
Periodontal disease (PDD) and rheumatoid arthritis (RMA) share comparative pathophysiological pathways like ongoingaggravation with resorption of the proximal bone in immunologically delicate hosts; However, PDD has a notable bacteriological etiology, and the cause of RMA remains unknown. According to some reports, an infectious agent in a vulnerable host may be the cause of RMA and
There is increasing evidence for the important role of gut microbiota (GMB) in the development and progression of neurologic pathologies. Some studies have shown that modifying the microbiome profile can confer benefits to patients. Mild traumatic brain injury (mTBI) is a common occurrence in the general population. Although most patients recover, in a minority, disabling