SCFA

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Metabolites, Pre-PD, Short Chain Fatty Acids /

We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as […]

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The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease

Biomarkers, Butyrate, Gut Microbiota, Gut-Brain axis, Metabolites, Short Chain Fatty Acids /

We found significantly altered SCFA levels in patients with autism spectrum disorder (ASD), affective disorders, multiple sclerosis (MS) and Parkinson’s disease (PD). NonSCFAs yielded less significantly distinct changes in faecal levels of patients and healthy controls, with the majority of findings were derived from urinary and blood samples. Preclinical studies have implicated different bacterial metabolites

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Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome– a pilot study

Anti-oxidants, Butyrate, Gut Microbiota, Metabolites, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

The modulatory effect of vitamins on the gut microbiome and related host health benefits remain largely unclear. We investigated the effects of colon-delivered vitamins A, B2, C, D, and E on the gut microbiota using a human clinical study and batch fermentation experiments, in combination with cell models for the assessment of barrier and immune

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Short-chain fatty acids in the context of Parkinson’s disease

A-Synuclein, Butyrate, Short Chain Fatty Acids /

Taken together, there is strong evidence that the gastrointestinal microbiome is altered in PD and this is similarly true for the composition of the intestinal metabolome. SCFAs are increasingly studied intestinal metabolites that have shown great potential to influence disease processes in neuroinflammatory disorders. Their role for neurodegenerative movement disorders such as PD is still

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Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson’s Disease – The RESISTA-PD Trial

Butyrate, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids, Therapies /

Clinically, we observed a reduction in non-motor symptoms load in PD + RS. The reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups, including bacteria producing SCFAs. Reference-free analysis suggested punctual, yet pronounced differences in the metagenomic signature in PD + RS. RESISTA-PD highlights that a prebiotic treatment with RS is

Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson’s Disease – The RESISTA-PD Trial Read More »

Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial

Diet and Exercise, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Our study demonstrates that ITF-prebiotic intake during 3 months decreases a fecal marker of intestinal inflammation in obese patients. Our data point to a potential contribution of microbial lipid-derived metabolites in gastro-intestinal dysfunction related to obesity. CLICK TO REVIEW

Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial Read More »

Advances of Mechanisms-Related Metabolomics in Parkinson’s Disease

Biomarkers, Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Mitochondria, Pre-PD, Short Chain Fatty Acids /

In this review, we briefly summarize recent findings and analyze the application of molecular metabolomics in familial and sporadic PD from genetic mutations, mitochondrial dysfunction, and dysbacteriosis. We also review metabolic biomarkers to assess the functional stage and improve therapeutic strategies to postpone or hinder the disease progression. CLICK TO REVIEW

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Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway

Anti-oxidants, Butyrate, Short Chain Fatty Acids, Vitamins / Supplements / Nutraceuticals /

Ochratoxin A (OTA) is a common environmental pollutant found in a variety of foods and grains, and excessive OTA consumptioncauses serious global health effects on animals and humans. Astaxanthin (AST) is a natural carotenoid that has anti-inflammatory,antiapoptotic, immunomodulatory, antitumor, antidiabetes, and other biological activities. The present study is aimed atinvestigating the effects of AST on

Astaxanthin Alleviates Ochratoxin A-Induced Cecum Injury and Inflammation in Mice by Regulating the Diversity of Cecal Microbiota and TLR4/MyD88/NF-κB Signaling Pathway Read More »

Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson’s Disease

Gut Microbiota, Short Chain Fatty Acids /

Increasing evidence is supporting the hypothesis of -synuclein pathology spreading from the gut to the brainalthough the exact etiology of Parkinson’s disease (PD) is unknown. Furthermore, it has been proposed that inflammation,via the gastrointestinal tract, potentially through infections, may contribute to -synuclein pathogenesis, and thus to the riskof developing PD. CLICK TO REVIEW

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