Spain

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Ayahuasca, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Uncategorized /

N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several South American countries. Here, we have examined, in vitro and vivo, the potential neurogenic effect of DMT. Our results demonstrate that DMT administration activates the main adult neurogenic niche, the subgranular zone of the dentate gyrus of […]

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Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients

Diet and Exercise, endondonics, Oral Microbiome, Parkinson's Disease, Pre-PD, Root Canal /

Oral disorders are frequent in PD. Good knowledge of these alterations will allow us to design a specific preventive protocol. Some oral alterations may be a sign of diagnostic alert or progression of PD. CLICK TO REVIEW

Facts and controversies regarding oral health in Parkinson’s disease:
A case-control study in Spanish patients Read More »

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Ayahuasca, Gut Microbiota /

There has been a renewed interest in the potential use of psychedelics for the treatment of psychiatric conditions. Nevertheless, little is known about the mechanism of action and molecular pathways influenced by ayahuasca use in humans. Therefore, for the first time, our study aims to investigate the human metabolomics signature after consumption of a psychedelic, ayahuasca, and its connection

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience Read More »

Fermented foods: an update on evidence-based health benefits and future perspectives

Probiotics, Prebiotics and Symbiotics /

In recent years, an unstoppable trend toward minimally processed foods has increased the popularity of fermented foods as a beneficial nutritional and functional strategy. Within food fermentations, complex microbial communities trigger different biochemical reactions that result in the release of multiple bioactive compounds with beneficial effect on human health. In the present review the latest

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Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity

Autonmic nervous system, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

: Over the last years, research has focused on microbiota to establish a missing link betweenneuronal health and intestine imbalance. Many studies have considered microbiota as criticalregulators of the gut–brain axis. The crosstalk between microbiota and the central nervous system ismainly explained through three different pathways: the neural, endocrine, and immune pathways,intricately interconnected with each

Impact of Contaminants on Microbiota: Linking the Gut–Brain
Axis with Neurotoxicity Read More »

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Anti-oxidants, Constipation, Diet and Exercise, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The fact that millions of people worldwide suffer from Alzheimer’s disease (AD) orParkinson’s disease (PD), the two most prevalent neurodegenerative diseases (NDs), has beena permanent challenge to science. New tools were developed over the past two decades andwere immediately incorporated into routines in many laboratories, but the most valuable scientificcontribution was the “waking up” of

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases Read More »

IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Short Chain Fatty Acids /

Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such as GLP-1,peptide YY, insulin, glucagon, ghrelin, leptin and serotonin while they also have animpact on the nervous system. Also is needed to emphasize its role in certainneurological diseases such as Parkinson, autism spectrum disorder and

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Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer’s and Parkinson’s Disease

Gut Microbiota, Mold, Mycotoxins, Olfactory, Parkinson's Disease /

In the case of PD, the fact that the disease is accompanied by other non-motor symptoms in organs highly exposed to the environment (olfactory and gastrointestinal systems) reinforces the hypotheses of the role of environmental factors in the etiology of PD. Many chemicals such as pesticides, metals (iron and lead), polychlorinated biphenyls, solvents such as

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Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder

A-Synuclein, Biomarkers, iRBD, Parkinson's Disease, Pre-PD /

Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression of LTS in iRBD patients. Our data also indicate that profiling of serum samples by NMR may be a useful tool for identifying short-term high-risk iRBD patients for conversion to parkinsonism or dementia. CLICK TO

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New Avenues for Parkinson’s Disease Therapeutics: Disease-Modifying Strategies Based on the Gut Microbiota

Biomarkers, Diet and Exercise, Fecal Transplants (FMT), Probiotics, Prebiotics and Symbiotics /

This review provides status on the different strategies that are in the front line (i.e., antibiotics; probiotics; prebiotics; synbiotics; dietary interventions; fecal microbiota transplantation, live biotherapeutic products), and discusses the opportunities and challenges the field of microbiome research in PD is facing.

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