Hyperbaric oxygen therapy (HBOT) has been suggested as a potential adjunctive therapy for Parkinson’s disease (PD). PD is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The aim of this study was to investigate the protective mechanisms of HBOT on neurons and motor function in […]
Individuals exposed to PID were 1.431 times more likely to develop PD than those who were not exposed. However, future long-term, larger or national data sets combined with genes, environmental exposure, lifestyle changes, dietary habits, and accurately defined PD diagnosis should be investigated to support the current research results. CLICK TO REVIEW
We are grateful for the comment on our study.1 We are pleased to know that short chain fatty acids (SCFA), especially butyrate, in the intestine could stimulate the colonization of curli-producing Escherichia coli (E. coli). Curli are functional amyloids produced by gut microbes and act as cross-beta-sheet amyloid polymers to assist bacterial cells in binding to
first_pagesettingsOpen AccessArticle Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson’s Disease by Hitesh Singh Chaouhan 1,†,Xin Li 1,†,Kuo-Ting Sun 2,3,†,I-Kuan Wang 4,5,Tung-Min Yu 6,7,Shao-Hua Yu 8,Kuen-Bao Chen 9,*,Wei-Yong Lin 10,11,12,* andChi-Yuan Li 1,9,*1Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan2Department of Pediatric Dentistry, China Medical University Hospital, Taichung 40402, Taiwan3School of Dentistry, China Medical University, Taichung
Background and Objectives: Short-chain fatty acids (SCFAs) are gut microbial metabolitesthat promote the disease process in a rodent model of Parkinson’s disease (PD), but fecallevels of SCFAs in PD patients are reduced. Simultaneous assessments of fecal and plasmaSCFA levels, and their inter-relationships with the PD disease process are scarce. We aimedto compare fecal and plasma
Autonomic nervous system (ANS) dysfunction contributes to several non-motor symptoms of Parkinson’s disease (PD). In addition, ANS plays a role in the genesis and maintenance of atrial fibrillation (AF). This study investigated the temporal association between PD and AF. This study demonstrated that the premotor and early stages of PD were comorbid with AF, whereas
The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation of this disease. Microbiota analysis has revealed increased Enterobacteria and decreased Prevotella strains in patients with PD (Scheperjans et al., 2015). Another clinical study found that, compared with healthy controls, patients with PD exhibited decreases in a range of
The gut microbiome: implications for neurogenesis and neurological diseases Read More »
PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the gut microbiota. L. plantarum abundance was significantly increased along with methionine biosynthesis-related microbial modules. PS128 also suppressed the increased family Enterobacteriaceae and lipopolysaccharide and peptidoglycan biosynthesis-related microbial modules caused by MPTP. In conclude, PS128 ingestion alleviated MPTP-induced motor deficits and
The hypothalamic–pituitary–adrenal axis was modulated by PS128 with decreased corticosterone concentration in serum and the expression of mineralocorticoid receptors in the amygdala. Oral administration of PS128 inhibited 5-HTPinduced VH during CRD. The ameliorative effect on VH suggests the potential application of PS128 for IBS. CLICK TO REVIEW