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Low-carbohydrate and ketogenic diets: a scoping review of neurological and inflammatory outcomes in human studies and their relevance to chronic pain

Diet and Exercise /

Dietary restriction of carbohydrates has been demonstrated to be beneficial for nervous system dysfunction in animal models and may be beneficial for human chronic pain. The purpose of this review is to assess the impact of a low-carbohydrate/ketogenic diet on the adult nervous system function and inflammatory biomarkers to inform nutritional research for chronic pain. […]

Low-carbohydrate and ketogenic diets: a scoping review of neurological and inflammatory outcomes in human studies and their relevance to chronic pain Read More »

Recent advances in understanding the roles of the enteric nervous system

Gut Microbiota, Gut-Brain axis, Parkinson's Disease /

The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal (GI) tract, is a vast, mesh-like network of neurons and glia embedded within the bowel wall. Through its complex circuitry and neuronal diversity, the ENS is capable of functioning autonomously but is modulated by inputs from the central nervous system (CNS). The communication between

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The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Permeability / Leaky Gut, Probiotics, Prebiotics and Symbiotics /

The gut microbiota is composed of several microbial strains, with diverse and variablecombinations in healthy and sick persons, changing at different stages of life. A healthy balancebetween host and gut microorganisms must be maintained in order to perform the normal physiological, metabolic, and immune functions and prevent disease development. Disturbances in the balanceof the gut

The Gut Microbiota Influenced by the Intake of Probiotics and
Functional Foods with Prebiotics Can Sustain Wellness and
Alleviate Certain Ailments like Gut-Inflammation and
Colon-Cancer Read More »

Predictors of RBD progression and conversion to synucleinopathies

Biomarkers, iRBD /

There is a variety of potential biomarkers for monitoring disease progression and predicting iRBD conversion into synucleinopathies. A combined multimodal biomarker model could offer a more sensitive and specific tool. Further longitudinal studies are warranted to iRBD as a high-risk population for early neuroprotective interventions and disease-modifying therapies. CLICK TO REVIEW

Predictors of RBD progression and conversion to synucleinopathies Read More »

Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans

A-Synuclein, Butyrate, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Recent discoveries have implicated the gut microbiome in the progression and severity of Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits a-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in

Probiotic Bacillus subtilis
Protects against a-Synuclein
Aggregation in C. elegans Read More »

The second brain in Parkinson’s disease: fact or fantasy?

Fecal Transplants (FMT), Gut Microbiota, Probiotics, Prebiotics and Symbiotics /

We have briefly expressed three components that are significant in promoting the complex involvement of the gut within PD. Thorough research has looked into the physiology and symptoms of PD, with further exploration into the gut microbiota a crucial step in truly understanding the disease process. Adopting strategies to ensure stable, healthy microbial consumption along

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The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport

A-Synuclein, ENS, Gut Dysbiosis, Gut Microbiota, Parkinson's Disease, Pre-PD /

Research has suggested a link between the gut microbiota and Parkinson’s Disease (PD), and an early involvement of gastrointestinal dysfunction has been reported in patients. A mechanism review was performed to investigate whether the neurodegenerative cascade begins in the gut; mediated by gut dysbiosis and retrograde transport of α-synuclein. This review provides a summary of

The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport Read More »

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

A-Synuclein, iRBD, Parkinson's Disease, Pre-PD /

Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However, whetherthe assay can be used as a robust, quantitative measure to monitor disease progression, stratifydifferent synucleinopathies and predict disease conversion in patients with idiopathic REMsleep behaviour disorder remains undetermined. The aim of this study was

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THE GUT-BRAIN AXIS: THE ROLE OF NUTRITION

Diet and Exercise, Gut-Brain axis, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics /

The gut-brain axis (GBA) refers to the bi-directional communication thatoccurs between the gut and the brain. Recently, studies have highlightedthe important role of nutrition in modulating the GBA. We will delve into thisexciting area of research and understand how certain diets and foods maybe linked to mood and mental health. Our understanding of the gut-brain

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Melatonin as first-line treatment for sleep disorders in Parkinson’s disease?

Biomarkers, iRBD, Pre-PD /

Sleep disturbance has been reported in up to 88%–98% of Parkinson’s disease patients; various sleep disorders can present even before motor symptoms. Rapid eye movement sleep behavior disorder (RBD), which can lead to violent dream enactment behavior, has a prevalence in Parkinson’s disease of 20% to 50% but best management of the condition is unclear.

Melatonin as first-line treatment for sleep disorders in Parkinson’s disease? Read More »