UK

Short-chain fatty acids as modulators of redox signaling in health and disease

Butyrate, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet, have been linked to beneficial effects on human health associated with their metabolic and signaling properties. Their physiological functions are related to their aliphatic tail length and dependent on the activation of specific membrane receptors. In this review, we focus on the mechanisms underlying […]

Short-chain fatty acids as modulators of redox signaling in health and disease Read More »

Parkinson’s disease: the nutrition perspective

Diet and Exercise, Parkinson's Disease, Pre-PD /

Parkinson‟s disease (PD) is the second most common neurodegenerative disease after Alzheimer‟sdisease and affects ~1% of the population over the age of 60 years in industrialised countries. Theaim of this review is to examine nutrition in PD across three domains: dietary intake and thedevelopment of PD; whole body metabolism in PD; and the effects of

Parkinson’s disease: the nutrition perspective Read More »

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations

Biomarkers, Parkinson's Disease, Pre-PD /

There are currently no consistent radiological findings for MPS, and pathological studies have shown that MPS, at least in the oldest old, are often underpinned by mixed neuropathologies, including those associated with Alzheimer’s disease, cerebrovascular disease, nigral neuronal loss, and Lewy bodies. Different subcategories of MPS appear to convey varying risk and specificity for PD

Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations Read More »

Neurogenic and anti-inflammatory effects of probiotics in Parkinson’s 3 disease: a systematic review of preclinical and clinical evidence

Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Findings from preclinical studies suggest that treatment with probiotics increased glucose metabolism (increased secretion of glucagon-like peptide-1), reduced peripheral and central inflammation (reduced interleukin-6 and tumor necrosis factor-α (TNF-α)), reduced peripheral and central oxidative stress (reduced peripheral superoxide anion levels and increased central antioxidant glutathione levels), decreased neurodegeneration (increased numbers of tyrosine hydroxylase dopaminergic neurons

Neurogenic and anti-inflammatory effects of probiotics in Parkinson’s 3 disease: a systematic review of preclinical and clinical evidence Read More »

Comparing the Results from Faecal Microbiome Transplantation (Fmt) and Gut Flora Replacement Therapy (Gfrt) using 16s Mrna Microbiome Mappin

Butyrate, Fecal Transplants (FMT), Parkinson's Disease /

We used the data from 10 randomly chosen patients from our cohort of FMT patients and the same for 10 randomly chosenpatients who had received GFRT. We measured their microbiomes using 16S mRNA tests, the results are shown in Tables 3 and 4. The reference values for the laboratory were used for these tests are

Comparing the Results from Faecal Microbiome Transplantation (Fmt) and Gut Flora Replacement Therapy (Gfrt) using 16s Mrna Microbiome Mappin Read More »

Early constipation predicts faster dementia onset
in Parkinson’s disease

Constipation, Dementia - Lewy Bodies /

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may bepart of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration,composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessedwith the MDS-UPDRS

Early constipation predicts faster dementia onset
in Parkinson’s disease Read More »

Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson’s disease

Biomarkers, Pre-PD /

Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population CLICK TO REVIEW

Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson’s disease Read More »

Is Chelation Therapy a Potential Treatment for Parkinson’s Disease

Iron, Parkinson's Disease /

The current use of chelators in clinical medicine is presented together with a discussion of two clinical trials of PD patients where an iron chelator was administered and showed encouraging results. It is proposed that the use of anti-inflammatory drugs combined with an iron chelator might be a better approach to increase chelator efficacy. CLICK

Is Chelation Therapy a Potential Treatment for Parkinson’s Disease Read More »

Dietary Influences on the Microbiota–Gut–Brain Axis

Diet and Exercise, Gut Dysbiosis, Gut Microbiota, Gut-Brain axis /

Finally, we should revise our view of the gut microbiota from that of a seething mass of microbes to one of organ-status, on which our health and wellbeing utterly depends. Future guidelines on lifestyle strategies for wellbeing should integrate advice on the optimal establishment and maintenance of a healthy gut microbiota through dietary and other

Dietary Influences on the Microbiota–Gut–Brain Axis Read More »

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila

A-Synuclein, Biomarkers, Pre-PD /

Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that impair neuronal function. The resultant synaptopathy causes behavioural deficits and progressive age-related neurodegeneration. Thissuccession of phenotypes recapitulates key events of dying-back like neurodegeneration5,27,92 and provide insights into the pathogenic mechanisms underlying synaptopathy, the likely initiating

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila Read More »