UK

Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

A-Synuclein, Biomarkers, Pre-PD /

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatographymass spectrometry (LC-MS) to analyse 274 samples […]

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Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

Biomarkers, Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Metabolites, Pre-PD, Short Chain Fatty Acids /

We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as

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