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Proof of Concept Study of Prebiotics to Modulate Gut Microbiome in Parkinson’s Disease

Butyrate, Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

Consumption of a novel prebiotic mixture rapidly impacted the intestinal microbiota (10 days), reduced the abundance of pro-inflammatory bacteria and promoted the growth of beneficial SCFA-producing bacteria. In addition, prebiotic consumption increased plasma SCFA levels, and improved markers of intestinal barrier integrity and brain health. This proof-of-concept study provides evidence for the importance of intestinal […]

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Quantitative and correlational analysis of gut-brain axis in
schizophrenia spectrum and mood disorders

Gut-Brain axis, Oral Microbiome /

The pathophysiology of schizophrenia spectrum disorders and associated mood disordersis complex and highly heterogeneous, suggesting that different molecular pathways are involvedin it. Among those, the microbiome and its connection to the brain (“gut-brain axis”) has emergedas a highly promising research avenue. To evaluate the role of the human microbiome in the gutbrain axis, we evaluated

Quantitative and correlational analysis of gut-brain axis in
schizophrenia spectrum and mood disorders Read More »

Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome

Gut Dysbiosis, Gut Microbiota, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics, Stroke /

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and theirhost. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional andfunctional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses todisease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability

Aging Microbiota-Gut-Brain Axis in Stroke Risk
and Outcome Read More »

Effects of a Ketogenic Diet on Symptoms, Biomarkers, Depression, and Anxiety in Parkinson’s Disease: A Case Study

Diet and Exercise, Parkinson's Disease /

The ketogenic diet has grown in popularity as an alternative or adjunct to medication therapy for Parkinson’s disease (PD) and other neurodegenerative diseases (NDD). Traditional medication therapies often fail to produce desired improvements in PD symptoms and can have little or no effect on symptoms of depression and anxiety that often accompany a PD diagnosis. We

Effects of a Ketogenic Diet on Symptoms, Biomarkers, Depression, and Anxiety in Parkinson’s Disease: A Case Study Read More »

The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Butyrate, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Short Chain Fatty Acids /

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential

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Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson’s disease

A-Synuclein, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α-synuclein (α-syn) in their colon. Both

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Food as Treatment of Inflammatory Bowel Diseases

Butyrate, Diet and Exercise, Gut Dysbiosis, Gut Microbiota /

Inflammatory bowel diseases (IBD), namely, Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong and incurable chronic inflammatory diseases affecting6.8 million people worldwide. By 2030, the prevalence of IBD is estimated to reach 1%of the population in Western countries, and thus there is an urgent need to developeffective therapies to reduce the burden of this

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Dietary manipulation of the gut microbiome in inflammatory bowel disease
patients: Pilot study

Diet and Exercise, Gut Dysbiosis, Probiotics, Prebiotics and Symbiotics /

Diet is a modifiable, noninvasive, inexpensive behavior that is crucial in shaping the intestinalmicrobiome. A microbiome “imbalance” or dysbiosis in inflammatory bowel disease (IBD) is linkedto inflammation. Here, we aim to define the impact of specific foods on bacterial species commonlydepleted in patients with IBD to better inform dietary treatment. We performed a single-arm, prepost

Dietary manipulation of the gut microbiome in inflammatory bowel disease
patients: Pilot study Read More »

Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis

A-Synuclein, Butyrate, Parkinson's Disease, Short Chain Fatty Acids /

Neurodegenerative protein conformational diseases are characterized by misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous work, suggest

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