The endocannabinoid system is a complex lipid signaling network that has evolved to
be a key regulator of pro-homeostatic pathways for the organism. Its involvement in numerous
processes has rendered it a very suitable target for pharmacological studies regarding metabolic
syndrome, obesity and other lifestyle-related diseases. Cannabinomimetic molecules have been
found in a large variety of foods, most of which are normally present in the Mediterranean diet.
The majority of these compounds belong to the terpene and polyphenol classes. While it is known
that they do not necessarily act directly on the cannabinoid receptors CB1 and CB2, their ability to
regulate their expression levels has already been shown in some disease-related models, as well as
their ability to modulate the activity of other components of the system. In this review, evidence was
gathered to support the idea that phytocannabinoid dietary intake may indeed be a viable strategy for
disease prevention and may be helpful in maintaining the health status. In an era where personalized
nutrition is becoming more and more a reality, having new therapeutic targets could become an
important resource. CLICK TO REVIEW
Keywords: Mediterranean diet; endocannabinoid system; terpenes; polyphenols; personalized
nutrition