The mechanisms involved in pathogenesis and progression of
PD is not fully understood but there is overwhelming evidence that
maintenance of redox potential is important for neuronal survival.
Any disruption in the mitochondrial potential disrupts the cellular
homeostasis, which in turn causes more ROS production leading
to neuroinflammation and degeneration. The review attempts to
consolidate key signaling pathways, and proteins that can be targeted
to develop therapeutics for Parkinson’s. The conventional medicine
is effective but has several side effects; hence developing small
molecules that can modify these molecular targets selectively can be
explored. CLICK TO REVIEW