Canada – Page 2

MIND and Mediterranean Diets Associated with Later Onset of Parkinson’s Disease

This cross-sectional study found a strong correlation between age of onset of PD and dietary habits, suggesting that nutritional strategies may be an effective tool to delay PD onset. Further studies may help to elucidate potential nutrition-related sex-specific pathophysiological mechanisms and differential prevalence rates in PD. CLICK TO REVIEW

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Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides

Inulin and GOS diets were associated with increased butyrate production and better anastomotic healing. Histological analysis revealed an enhanced mucosal continuity, and this was associated with an increased re-epithelialization of the wound as determined by increased epithelial proliferation. Collagen concentration in peri-anastomotic tissue was higher with inulin and GOS diets and MMP activity, a marker

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Boxing with Parkinson’s Disease: findings from a qualitative study using self-determination theory

Diet and Exercise, Parkinson's Disease, Pre-PD / Rob

Adults with Parkinson’s disease (PD) experience debilitating symptoms that may be mitigated by boxing. Yet, attrition from boxing programs is problematic. Understanding whether PD-specific boxing programs can enhance motivation to remain physically active is important. This study investigated adults’ experiences within a PD-specific boxing program and explored their perspectives on how the program has influenced

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Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models

A-Synuclein, Pre-PD / Rob

Tat-βsyndegron decreased α-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing human A53T α-synuclein. Moreover, Tat-βsyn-degron reduced α-synuclein levels and significantly decreased the parkinsonian toxin-induced neuronal damage and motor impairment in a mouse toxicity model of PD. These results show the promising efficacy of Tat-βsyn-degron in

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models Read More »